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S Jacobitz

Explore the profile of S Jacobitz including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 56
Followers 0
Related Specialties
Microbiology
Pharmacology
Molecular Biology
Top 10 Co-Authors
T J Torphy
P E Bishop
G A Omburo
G P Livi
M M McLaughlin
R W Colman
G Kruskemper
R F Colman
M D Ryan
S C Ricke
Published In
J Bacteriol
Mol Pharmacol
Methods Inf Med Suppl
Blood
Cell Signal
Affiliations
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Recent Articles
1.
Critical role of conserved histidine pairs HNXXH and HDXXH in recombinant human phosphodiesterase 4A
Omburo G, Jacobitz S, Torphy T, Colman R
Cell Signal . 1998 Oct; 10(7):491-7. PMID: 9754717
Cyclic AMP-Phosphodiesterases (cAMP-PDEs) catalyse the hydrolysis cAMP to AMP and thus serve to modulate the ligand-->adenylate cyclase-->cAMP-->PKA signal transduction pathway. PDEs exist as a multigene family of enzymes that bear...
2.
Role of conserved histidines in catalytic activity and inhibitor binding of human recombinant phosphodiesterase 4A
Jacobitz S, Ryan M, McLaughlin M, Livi G, DeWolf Jr W, Torphy T
Mol Pharmacol . 1997 Jun; 51(6):999-1006. PMID: 9187266
To identify critical amino acids within the central conserved region of recombinant human cAMP-specific phosphodiesterase 4 subtype A (rhPDE4A), we engineered the expression of point mutants in a fully active...
3.
Inactivation of recombinant monocyte cAMP-specific phosphodiesterase by cAMP analog, 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic monophosphate
Omburo G, Torphy T, Scott G, Jacobitz S, Colman R, Colman R
Blood . 1997 Feb; 89(3):1019-26. PMID: 9028334
Two cAMP analogs, 8- and 2- [(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic monophosphate (8- and 2-BDB-TcAMP) have been used in probing the catalytic site of recombinant monocyte cAMP-specific phosphodiesterase (PDE4a). 2-BDB-TcAMP is a reversible...
4.
Mapping the functional domains of human recombinant phosphodiesterase 4A: structural requirements for catalytic activity and rolipram binding
Jacobitz S, McLaughlin M, Livi G, Burman M, Torphy T
Mol Pharmacol . 1996 Oct; 50(4):891-9. PMID: 8863835
To identify functional domains of the 886-amino acid human recombinant cAMP-specific phosphodiesterase (PDE) subtype A (rhPDE4A), we engineered the expression of seven mutant proteins containing both NH2- and COOH-terminal truncations....
5.
Phenotypic characterization of a tungsten-tolerant mutant of Azotobacter vinelandii
Premakumar R, Jacobitz S, Ricke S, Bishop P
J Bacteriol . 1996 Feb; 178(3):691-6. PMID: 8550501
A tungsten-tolerant mutant strain (CA6) of Azotobacter vinelandii first described in 1980 (P. E. Bishop, D. M. L. Jarlenski, and D. R. Hetherington, Proc. Natl. Acad. Sci. USA 77:7342-7346, 1980)...
6.
Regulation of nitrogenase-2 in Azotobacter vinelandii by ammonium, molybdenum, and vanadium
Jacobitz S, Bishop P
J Bacteriol . 1992 Jun; 174(12):3884-8. PMID: 1597411
Under diazotrophic conditions in the absence of molybdenum and in the presence of vanadium, Azotobacter vinelandii reduces N2 to NH4+ by using nitrogenase-2, a V-containing enzyme complex encoded by vnfH...
7.
Removal of CO dehydrogenase from Pseudomonas carboxydovorans cytoplasmic membranes, rebinding of CO dehydrogenase to depleted membranes, and restoration of respiratory activities
Jacobitz S, Meyer O
J Bacteriol . 1989 Nov; 171(11):6294-9. PMID: 2808305
In Pseudomonas carboxydovorans, CO dehydrogenase and hydrogenase were found in association with the cytoplasmic membrane in a weakly bound and a tightly bound pool. The pools could be experimentally distinguished...
8.
[Psychometric and psychosomatic results in the evaluation of patient samples in ambulatory care of thyroid diseases using a general program system]
Jacobitz K, Jacobitz S, KRUSKEMPER H, Kruskemper G
Methods Inf Med Suppl . 1976 Jan; 9:361-8. PMID: 1078446
No abstract available.