Alpha 2.0
Login Register
» Authors » S I Gringhuis

S I Gringhuis

Explore the profile of S I Gringhuis including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 88
Followers 0
Related Specialties
Allergy & Immunology
Biochemistry
Cell Biology
Top 10 Co-Authors
E Vellenga
L F de Leij
P Borger
C F Calkhoven
P H Remans
D S Postma
C L Verweij
C Lummen
J A Timmerman
H Tokumitsu
Published In
Gene
Mol Cell Biol
Blood
J Allergy Clin Immunol
J Biol Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis
Gringhuis S, Leow A, Remans P, Breedveld F, Verweij C
J Immunol . 2000 Feb; 164(4):2170-9. PMID: 10657671
The T lymphocytes that reside in the synovium of the inflamed joints in patients with rheumatoid arthritis display severe hyporesponsiveness upon antigenic stimulation, which is probably due to their constant...
2.
Prostaglandin E2 differentially modulates IL-5 gene expression in activated human T lymphocytes depending on the costimulatory signal
Borger P, Vellenga E, Gringhuis S, Timmerman J, Lummen C, Postma D, et al.
J Allergy Clin Immunol . 1998 Mar; 101(2 Pt 1):231-40. PMID: 9500757
Background: Protein kinase A (PKA) activation is documented to be inhibitory for T helper cell (T[H1])-like cytokines (IL-2, IFN-gamma), whereas T(H2)-like cytokines (IL-4, IL-5) are not affected or upregulated. We...
3.
Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes
Gringhuis S, de Leij L, Coffer P, Vellenga E
Mol Cell Biol . 1998 Mar; 18(3):1725-35. PMID: 9488489
CD5 acts as a coreceptor on T lymphocytes and plays an important role in T-cell signaling and T-cell-B-cell interactions. Costimulation of T lymphocytes with anti-CD5 antibodies results in an increase...
4.
The Ca2+/calmodulin-dependent kinase type IV is involved in the CD5-mediated signaling pathway in human T lymphocytes
Gringhuis S, de Leij L, Wayman G, Tokumitsu H, Vellenga E
J Biol Chem . 1998 Feb; 272(50):31809-20. PMID: 9395527
The CD5 receptor on T lymphocytes is involved in T cell activation and T-B cell interactions. In the present study, we have characterized the signaling pathways induced by anti-CD5 stimulation...
5.
Interleukin-7 upregulates the interleukin-2-gene expression in activated human T lymphocytes at the transcriptional level by enhancing the DNA binding activities of both nuclear factor of activated T cells and activator protein-1
Gringhuis S, de Leij L, Verschuren E, Borger P, Vellenga E
Blood . 1997 Nov; 90(7):2690-700. PMID: 9326236
In the present report, we studied the role of the stromal-derived cytokine interleukin-7 (IL-7) in the IL-2-gene regulation in activated T lymphocytes. Production of IL-2 requires the formation of transcription...
6.
The chicken CCAAT/enhancer binding protein alpha gene. Cloning, characterisation and tissue distribution
Calkhoven C, Gringhuis S, Ab G
Gene . 1997 Oct; 196(1-2):219-29. PMID: 9322761
We present the cloning and sequencing of the gene encoding the chicken CCAAT/Enhancer Binding Protein alpha (cC/EBP alpha). The coding region and 1.5 kb of 5' flanking DNA from a...