S H Zigmond
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Explore the profile of S H Zigmond including associated specialties, affiliations and a list of published articles.
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69
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Recent Articles
1.
Zigmond S, Foxman E, Segall J
Curr Protoc Cell Biol
. 2008 Jan;
Chapter 12:Unit 12.1.
PMID: 18228315
Chemotaxis is a complex response of a cell to an external stimulus. It involves detecting and measuring the concentration of the chemoattractant, biochemical transmission of the information, and the motility...
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Yang C, Huang M, DeBiasio J, Pring M, Joyce M, Miki H, et al.
J Cell Biol
. 2000 Sep;
150(5):1001-12.
PMID: 10973991
We find that profilin contributes in several ways to Cdc42-induced nucleation of actin filaments in high speed supernatant of lysed neutrophils. Depletion of profilin inhibited Cdc42-induced nucleation; re-addition of profilin...
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Huang M, Yang C, Schafer D, Cooper J, Higgs H, Zigmond S
Curr Biol
. 1999 Oct;
9(17):979-82.
PMID: 10508585
Each actin filament has a pointed and a barbed end, however, filament elongation occurs primarily at the barbed end. Capping proteins, by binding to the barbed end, can terminate this...
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Bi E, Zigmond S
Curr Biol
. 1999 Mar;
9(5):R160-3.
PMID: 10074445
How do extracellular signals induce actin polymerization, as required for many cellular responses? Key signal transducers, such as the small GTPases Cdc42 and Rac, have now been shown to link...
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Zigmond S
Curr Biol
. 1998 Sep;
8(18):R654-7.
PMID: 9740796
Actin filament polymerization results primarily from the addition of monomers to pre-existing filaments. Recent studies have revealed that the Arp2/3 protein complex, which includes two actin-related proteins, can nucleate new...
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Zigmond S, Joyce M, Yang C, Brown K, Huang M, Pring M
J Cell Biol
. 1998 Aug;
142(4):1001-12.
PMID: 9722612
Cdc42, activated with GTPgammaS, induces actin polymerization in supernatants of lysed neutrophils. This polymerization, like that induced by agonists, requires elongation at filament barbed ends. To determine if creation of...
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Zigmond S, Joyce M, Borleis J, Bokoch G, Devreotes P
J Cell Biol
. 1997 Jul;
138(2):363-74.
PMID: 9230078
We have established a cell-free system to investigate pathways that regulate actin polymerization. Addition of GTPgammaS to lysates of polymorphonuclear leukocytes (PMNs) or Dictyostelium discoideum amoeba induced formation of filamentous...