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S H Phelps

Explore the profile of S H Phelps including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 76
Followers 0
Related Specialties
Biochemistry
Pharmacology
Oncology
Top 10 Co-Authors
C L Williams
R A Porter
H L Puhl
D Strassheim
S H Shafer
R S Aronstam
L G May
K A Varker
S M Stair
J D Noti
Published In
Biochem Pharmacol
J Biol Chem
Alcohol Clin Exp Res
Cancer Res
Exp Cell Res
Affiliations
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Recent Articles
1.
Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma
Strassheim D, Shafer S, Phelps S, Williams C
Cancer Res . 2000 May; 60(10):2730-6. PMID: 10825148
Aberrant signal transduction pathways involved in the development of metastatic disease are poorly defined in both small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). Neuropeptide-driven positive feedback...
2.
Unique in vivo associations with SmgGDS and RhoGDI and different guanine nucleotide exchange activities exhibited by RhoA, dominant negative RhoA(Asn-19), and activated RhoA(Val-14)
Strassheim D, Porter R, Phelps S, Williams C
J Biol Chem . 2000 Mar; 275(10):6699-702. PMID: 10702222
We compared the in vivo characteristics of hemagglutinin (HA)-tagged RhoA, dominant negative RhoA(Asn-19), and activated RhoA(Val-14) stably expressed in Chinese hamster ovary (CHO) cells. Proteins co-precipitating with these HA-tagged GTPases...
3.
M3 muscarinic acetylcholine receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein kinase C isoforms
Strassheim D, May L, Varker K, Puhl H, Phelps S, Porter R, et al.
J Biol Chem . 1999 Jun; 274(26):18675-85. PMID: 10373480
Although muscarinic acetylcholine receptors (mAChR) regulate the activity of smooth muscle myosin, the effects of mAChR activation on cytoplasmic myosin have not been characterized. We found that activation of transfected...
4.
Activation of transfected M1 or M3 muscarinic acetylcholine receptors induces cell-cell adhesion of Chinese hamster ovary cells expressing endogenous cadherins
Shafer S, Puhl H, Phelps S, Williams C
Exp Cell Res . 1999 Mar; 248(1):148-59. PMID: 10094822
Expression of endogenous cadherins by Chinese hamster ovary (CHO) cells has not been previously reported. However, we observed that CHO cells adhere to one another upon activation of transfected muscarinic...
5.
Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors
Shafer S, Phelps S, Williams C
Biochem Pharmacol . 1998 Nov; 56(9):1229-36. PMID: 9802335
This study investigated the effects of the adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase inhibitors caffeine, theophylline, and 3-isobutyl-1-methyl-xanthine (IBMX) on the proliferation and viability of the small cell lung carcinoma (SCLC)...
6.
Ethanol disrupts carbamylcholine-stimulated release of arachidonic acid from Chinese hamster ovary cells expressing different subtypes of human muscarinic receptor
Stair S, May L, Puhl H, Phelps S, Williams C, Aronstam R
Alcohol Clin Exp Res . 1998 May; 22(2):409-15. PMID: 9581647
Ethanol disrupts signal transduction mediated by a variety of G-protein coupled receptors. We examined the effects of ethanol on arachidonic acid release mediated by muscarinic acetylcholine receptors. Chinese hamster ovary...
7.
Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in...
Williams C, Phelps S, Porter R
Biochem Pharmacol . 1996 Mar; 51(5):707-15. PMID: 8615909
Because changes in intracellular Ca2+ affect progression through the mitotic cell cycle, we investigated the role of Ca2+-binding proteins in regulating cell cycle progression. Evidence was found demonstrating that the...
8.
Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine)
Williams C, Porter R, Phelps S
Biochem Pharmacol . 1995 Dec; 50(12):1979-85. PMID: 8849323
Although small cell lung carcinoma (SCLC) cells express both voltage-gated Ca2+ channels (VGCC) and second messenger-operated Ca2+ channels (SMOCC), little is known about the factors that regulate the activity of...