S H Hughes
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Explore the profile of S H Hughes including associated specialties, affiliations and a list of published articles.
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200
Citations
5923
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Recent Articles
1.
Maldarelli F, Wu X, Su L, Simonetti F, Shao W, Hill S, et al.
Science
. 2014 Jun;
345(6193):179-83.
PMID: 24968937
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the...
2.
McWilliams M, Julias J, Hughes S
J Virol
. 2008 Mar;
82(10):5104-8.
PMID: 18321979
Previously, we analyzed the effects of point mutations in the human immunodeficiency virus type 1 (HIV-1) polypurine tract (PPT) and found that some mutations affected both titer and cleavage specificity....
3.
Gao H, Sarafianos S, Arnold E, Hughes S
J Virol
. 2001 Nov;
75(23):11874-80.
PMID: 11689669
The synthesis of retroviral DNA is initiated near the 5' end of the RNA. DNA synthesis is transferred from the 5' end to the 3' end of viral RNA in...
4.
Peletskaya E, Boyer P, Kogon A, Clark P, KROTH H, Sayer J, et al.
J Virol
. 2001 Sep;
75(19):9435-45.
PMID: 11533206
Cross-linking experiments were performed with human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutants with unique cysteine residues at several positions (positions 65, 67, 70, and 74) in the...
5.
Sevilya Z, Loya S, Hughes S, Hizi A
J Mol Biol
. 2001 Sep;
311(5):957-71.
PMID: 11531332
Retroviral reverse transcriptases (RTs) have both DNA polymerase and ribonuclease H (RNase H) activities. The RTs of HIV-1 and HIV-2 are heterodimers of p66/p51 and p68/p54 subunits, respectively. The smaller...
6.
Golinelli M, Hughes S
Virology
. 2001 Jul;
285(2):278-90.
PMID: 11437662
After minus-strand strong-stop DNA (-sssDNA) is synthesized, the RNA template is degraded by the RNase H activity of the reverse transcriptase (RT), generating a single-stranded DNA. The 3' end of...
7.
8.
Julias J, Ferris A, Boyer P, Hughes S
J Virol
. 2001 Jun;
75(14):6537-46.
PMID: 11413321
The amount of excess polymerase and RNase H activity in human immunodeficiency virus type 1 virions was measured by using vectors that undergo a single round of replication. Vectors containing...
9.
Boyer P, Gao H, CLARK P, Sarafianos S, Arnold E, Hughes S
J Virol
. 2001 Jun;
75(14):6321-8.
PMID: 11413298
When human immunodeficiency virus type 1 (HIV-1) is selected for resistance to 3TC, the methionine normally present at position 184 is replaced by valine or isoleucine. Position 184 is the...
10.
Hsiou Y, Ding J, Das K, Clark Jr A, Boyer P, Lewi P, et al.
J Mol Biol
. 2001 May;
309(2):437-45.
PMID: 11371163
Inhibitors of human immunodeficiency virus (HIV) reverse transcriptase (RT) are widely used in the treatment of HIV infection. Loviride (an alpha-APA derivative) and HBY 097 (a quinoxaline derivative) are two...