S E Halford
Overview
Explore the profile of S E Halford including associated specialties, affiliations and a list of published articles.
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Articles
93
Citations
1241
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Recent Articles
1.
Barman T, Bellamy S, GUTFREUND H, Halford S, Lionne C
Cell Mol Life Sci
. 2006 Sep;
63(22):2571-83.
PMID: 16952048
Traditionally, enzyme transient kinetics have been studied by the stopped-flow and rapid quench-flow (QF) methods. Whereas stopped-flow is the more convenient, it suffers from two weaknesses: optically silent systems cannot...
2.
Johnson V, Volikos E, Halford S, Eftekhar Sadat E, Popat S, Talbot I, et al.
Gut
. 2005 Jan;
54(2):264-7.
PMID: 15647192
Background And Aims: Activating beta-catenin mutations in exon 3 have been implicated in colorectal tumorigenesis. Although reports to the contrary exist, it has been suggested that beta-catenin mutations occur more...
3.
Halford S
Biochem Soc Trans
. 2001 Aug;
29(Pt 4):363-74.
PMID: 11497991
Type II restriction endonucleases recognize specific DNA sequences and cleave both strands of the DNA at fixed locations at or near their recognition sites. Many of these enzymes are dimeric...
4.
Milsom S, Halford S, Embleton M, Szczelkun M
J Mol Biol
. 2001 Aug;
311(3):515-27.
PMID: 11493005
Before cleaving DNA substrates with two recognition sites, the Cfr10I, NgoMIV, NaeI and SfiI restriction endonucleases bridge the two sites through 3D space, looping out the intervening DNA. To characterise...
5.
Embleton M, Siksnys V, Halford S
J Mol Biol
. 2001 Aug;
311(3):503-14.
PMID: 11493004
Several type II restriction endonucleases interact with two copies of their target sequence before they cleave DNA. Three such enzymes, NgoMIV, Cfr10I and NaeI, were tested on plasmids with one...
6.
Williams S, Halford S
Nucleic Acids Res
. 2001 Mar;
29(7):1476-83.
PMID: 11266549
The SfiI endonuclease cleaves DNA at the sequence GGCCNNNN NGGCC, where N is any base and downward arrow is the point of cleavage. Proteins that recognise discontinuous sequences in DNA...
7.
Stanford N, Szczelkun M, Marko J, Halford S
EMBO J
. 2000 Dec;
19(23):6546-57.
PMID: 11101527
Proteins that interact with specific DNA sites bind to DNA at random and then translocate to the target site. This may occur by one-dimensional diffusion along the DNA, or through...
8.
Halford S, Gowers D, Sessions R
Nat Struct Biol
. 2000 Aug;
7(9):705-7.
PMID: 10966631
No abstract available.
9.
Halford S, Bilcock D, Stanford N, Williams S, Milsom S, Gormley N, et al.
Biochem Soc Trans
. 2000 Aug;
27(4):696-9.
PMID: 10917669
No abstract available.
10.
Watson M, Gowers D, Halford S
J Mol Biol
. 2000 Apr;
298(3):461-75.
PMID: 10772863
Many processes are governed by proteins that bind to separate sites in DNA and loop out the intervening DNA, but the geometries of the loops have seldom been determined. The...