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S C Tovey

Explore the profile of S C Tovey including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 520
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Recent Articles
1.
Tovey S, Dedos S, Taylor C
Biochem Soc Trans . 2006 Jul; 34(Pt 4):515-7. PMID: 16856848
PTH (parathyroid hormone), acting via type 1 PTH receptors, is a major regulator of plasma [Ca(2+)]. The G-protein, G(s), is an essential component of the sequence linking PTH to plasma...
2.
Tovey S, de Smet P, Lipp P, Thomas D, Young K, Missiaen L, et al.
J Cell Sci . 2001 Dec; 114(Pt 22):3979-89. PMID: 11739630
Elementary Ca(2+) signals, such as "Ca(2+) puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca(2+) signalling. We characterized Ca(2+) puffs in...
3.
Bootman M, Collins T, Peppiatt C, Prothero L, Mackenzie L, de Smet P, et al.
Semin Cell Dev Biol . 2001 Feb; 12(1):3-10. PMID: 11162741
Calcium (Ca2+) is an almost universal intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation. The ability of a simple ion...
4.
Hughes P, McLellan H, Lowes D, Kahn S, Bilmen J, Tovey S, et al.
Biochem Biophys Res Commun . 2000 Nov; 277(3):568-74. PMID: 11061995
Industrial alkylphenols in the environment may act as "xenoestrogens" to disrupt testicular development and decrease male fertility. Amongst possible targets for these compounds are testicular Sertoli cells, which nurture the...
5.
Tovey S, Dyer J, Godfrey R, Khan S, Bilmen J, Mezna M, et al.
Pharmacol Res . 2000 Nov; 42(6):581-90. PMID: 11058412
One of the major mechanisms by which hormones elevate intracellular Ca(2+)levels is by generating the second messenger inositol 1,4, 5-trisphosphate (InsP(3)), which activates a Ca(2+)channel (InsP(3)receptor) located in the endoplasmic...
6.
Thomas D, Tovey S, Collins T, Bootman M, Berridge M, Lipp P
Cell Calcium . 2000 Oct; 28(4):213-23. PMID: 11032777
Quantifying the magnitude of Ca2+ signals from changes in the emission of fluorescent indicators relies on assumptions about the indicator behaviour in situ. Factors such as osmolarity, pH, ionic strength...
7.
Tovey S, Bootman M, Lipp P, Berridge M, Bram R
Biochem Biophys Res Commun . 2000 Sep; 276(1):97-100. PMID: 11006089
The Ca(2+)-modulating cyclophilin ligand (CAML) protein causes stimulation of transcription factors via activation of a store-operated Ca(2+) entry pathway. Since CAML is widely expressed in mammalian tissues, it may be...
8.
Lipp P, Laine M, Tovey S, Burrell K, Berridge M, Li W, et al.
Curr Biol . 2000 Aug; 10(15):939-42. PMID: 10959844
The roles of the Ca2+-mobilising messenger inositol 1,4,5-trisphosphate (InsP3) in heart are unclear, although many hormones activate InsP3 production in cardiomyocytes and some of their inotropic, chronotropic and arrhythmogenic effects...
9.
Bootman M, Thomas D, Tovey S, Berridge M, Lipp P
Cell Mol Life Sci . 2000 May; 57(3):371-8. PMID: 10823238
The topic of nuclear Ca2+ signalling is beset by discrepant observations of substantial nuclear/cytoplasmic gradients. The reasons why some labs have recorded such gradients, whilst other workers see equilibration of...
10.
Thomas D, Lipp P, Tovey S, Berridge M, Li W, Tsien R, et al.
Curr Biol . 2000 Feb; 10(1):8-15. PMID: 10660296
Background: Elementary Ca2+ signals, such as 'Ca2+ puffs', that arise from the activation of clusters of inositol 1 ,4,5,-trisphosphate (InsP3) receptors are the building blocks for local and global Ca2+...