S C Chua Jr
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Explore the profile of S C Chua Jr including associated specialties, affiliations and a list of published articles.
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34
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1063
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Recent Articles
1.
Eerola K, Nordlund W, Virtanen S, Dickens A, Mattila M, Ruohonen S, et al.
J Neuroendocrinol
. 2013 Oct;
25(12):1298-1307.
PMID: 24118213
Melanocyte stimulating hormone (MSH) derived from the pro-hormone pro-opiomelanocortin (POMC) has potent effects on metabolism and feeding that lead to reduced body weight in the long-term. To determine the individual...
2.
Guo X, Roberts M, Becker S, Podd B, Zhang Y, Chua Jr S, et al.
Mucosal Immunol
. 2010 Dec;
4(3):294-303.
PMID: 21124310
Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that...
3.
Ho G, Melman A, Liu S, Li M, Yu H, Negassa A, et al.
Br J Cancer
. 2003 Mar;
88(2):263-9.
PMID: 12610512
High insulin levels are linked with increased cancer risk, including prostate cancer. We examined the associations between prostate cancer with polymorphisms of the insulin gene (INS) and its neighbouring genes,...
4.
Korner J, Savontaus E, Chua Jr S, Leibel R, Wardlaw S
J Neuroendocrinol
. 2001 Dec;
13(11):959-66.
PMID: 11737554
Agouti-related protein (AGRP) is synthesized in the same neurones in the arcuate nucleus as neuropeptide Y (NPY), another potent orexigenic peptide. AGRP antagonizes the action of alpha-melanocyte stimulating hormone, a...
5.
Ko C, Lee T, Lau P, Li J, Davis B, Voyiaziakis E, et al.
J Lipid Res
. 2001 May;
42(5):844-55.
PMID: 11352992
An elevated plasma apolipoprotein B (apoB) level is a strong predictor of atherosclerosis and coronary heart disease. Epidemiologic and family linkage studies have suggested a genetic basis for the wide...
6.
Kowalski T, Liu S, Leibel R, Chua Jr S
Diabetes
. 2001 Mar;
50(2):425-35.
PMID: 11272157
Mice homozygous for the Leprdb3J (db3J) mutation are null for all known isoforms of the leptin receptor (LEPR). These animals are obese, hyperphagic, cold intolerant, insulin resistant, and infertile. Mice...
7.
Korner J, Wardlaw S, Liu S, Conwell I, Leibel R, Chua Jr S
Endocrinology
. 2000 Jun;
141(7):2465-71.
PMID: 10875247
Agouti-related protein provides an orexigenic signal, probably through interaction with central melanocortin receptors. Expression of Agrp is markedly increased in the hypothalamus of mice deficient in leptin (Lep(ob)/Lep(ob)) or its...
8.
Brown J, Chua Jr S, Liu S, Andrews M, Vandenbergh J
Am J Physiol Regul Integr Comp Physiol
. 2000 Feb;
278(2):R320-30.
PMID: 10666131
Five allelic mutants of the diabetes (db) gene have been previously described in mice and rats causing obesity, infertility, and varying degrees of diabetes. We have identified a new, spontaneous...
9.
Korner J, Chua Jr S, Williams J, Leibel R, Wardlaw S
Neuroendocrinology
. 2000 Feb;
70(6):377-83.
PMID: 10657730
The mechanisms by which leptin influences energy homeostasis are not entirely understood. Several observations indicate that proopiomelanocortin (POMC) is involved in the regulation of food intake and may be a...
10.
Kowalski T, Houpt T, Jahng J, Okada N, Liu S, Chua Jr S, et al.
Physiol Behav
. 1999 Nov;
67(4):521-5.
PMID: 10549888
Hypothalamic preproNPY overexpression in the Zucker fatty (fa/fa) rat was examined. In situ hybridization was used to determine the relative level of preproNPY mRNA in the arcuate nucleus of +/+,...