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S Benjannet

Explore the profile of S Benjannet including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 70
Citations 1359
Followers 0
Related Specialties
Biochemistry
Science
Neurology
Top 10 Co-Authors
N G Seidah
M Chretien
C Lazure
M Marcinkiewicz
M Lis
J Hamelin
D Savaria
P Crine
J S Munzer
M Mbikay
Published In
FEBS Lett
Biochem Biophys Res Commun
J Biol Chem
Biochem J
Proc Natl Acad Sci U S A
Affiliations
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Recent Articles
1.
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production
Benjannet S, Elagoz A, Wickham L, Mamarbachi M, Munzer J, Basak A, et al.
J Biol Chem . 2001 Jan; 276(14):10879-87. PMID: 11152688
Processing of the beta-amyloid precursor protein (betaAPP) by beta- and gamma-secretases generates the amyloidogenic peptide Abeta, a major factor in the etiology of Alzheimer's disease. Following the recent identification of...
2.
Regional and cellular localization of the neuroendocrine prohormone convertases PC1 and PC2 in the rat central nervous system
Winsky-Sommerer R, Benjannet S, Rovere C, Barbero P, Seidah N, Epelbaum J, et al.
J Comp Neurol . 2000 Jul; 424(3):439-60. PMID: 10906712
PC1 and PC2 are two major enzymes involved in the processing of protein precursors directed to the regulated secretory pathway. Whereas transcripts encoding both enzymes are widely distributed in the...
3.
The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
Seidah N, Benjannet S, Hamelin J, Mamarbachi A, Basak A, Marcinkiewicz J, et al.
Ann N Y Acad Sci . 2000 May; 885:57-74. PMID: 10816641
Proopiomelanocortin (POMC) is a precursor to various, bioactive peptides including ACTH, beta LPH, alpha MSH, and beta endorphin (beta END). Processing of POMC at dibasic residues is tissue-specific and is...
4.
Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7
Lissitzky J, Luis J, Munzer J, Benjannet S, Parat F, Chretien M, et al.
Biochem J . 2000 Feb; 346 Pt 1:133-8. PMID: 10657249
Several integrin alpha subunits undergo post-translational endoproteolytic processing at pairs of basic amino acids that is mediated by the proprotein convertase furin. Here we ask whether other convertase family members...
5.
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment
Toure B, Munzer J, Basak A, Benjannet S, Rochemont J, Lazure C, et al.
J Biol Chem . 2000 Jan; 275(4):2349-58. PMID: 10644685
Biochemical and enzymatic characterization of the novel human subtilase hSKI-1 was carried out in various cell lines. Within the endoplasmic reticulum of LoVo cells, proSKI-1 is converted to SKI-1 by...
6.
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
Zhong M, Munzer J, Basak A, Benjannet S, Mowla S, Decroly E, et al.
J Biol Chem . 1999 Nov; 274(48):33913-20. PMID: 10567353
All proprotein convertases (PCs) of the subtilisin/kexin family contain an N-terminal prosegment that is presumed to act both as an intramolecular chaperone and an inhibitor of its parent enzyme. In...
7.
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
Seidah N, Mowla S, Hamelin J, Mamarbachi A, Benjannet S, Toure B, et al.
Proc Natl Acad Sci U S A . 1999 Feb; 96(4):1321-6. PMID: 9990022
Using reverse transcriptase-PCR and degenerate oligonucleotides derived from the active-site residues of subtilisin/kexin-like serine proteinases, we have identified a highly conserved and phylogenetically ancestral human, rat, and mouse type I...
8.
The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells
Girardin S, Benjannet S, Barale J, Chretien M, Seidah N
FEBS Lett . 1998 Aug; 431(3):333-8. PMID: 9714537
mLIM3, a member of the LIM homeobox family, was recently demonstrated to be critical for proliferation and differentiation of the pituitary cell lineage. Using a pool of degenerate oligonucleotides we...
9.
Residues unique to the pro-hormone convertase PC2 modulate its autoactivation, binding to 7B2 and enzymatic activity
Benjannet S, Mamarbachi A, Hamelin J, Savaria D, Munzer J, Chretien M, et al.
FEBS Lett . 1998 Jun; 428(1-2):37-42. PMID: 9645470
The prohormone convertase PC2 is one of the major subtilisin/kexin-like enzymes responsible for the formation of small bioactive peptides in neural and endocrine cells. This convertase is unique among the...
10.
Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway
Benjannet S, Savaria D, Laslop A, Munzer J, Chretien M, Marcinkiewicz M, et al.
J Biol Chem . 1997 Oct; 272(42):26210-8. PMID: 9334189
We studied the extent of cellular inhibitory activity of alpha1-antitrypsin Portland (alpha1-PDX), a potent inhibitor of proprotein convertases of the subtilisin/kexin type. We compared the inhibitory effects of alpha1-PDX on...