S A Proefke
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Explore the profile of S A Proefke including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
136
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Recent Articles
1.
Wong S, Zhang L, Witt T, Proefke S, Bhushan A, Matherly L
J Biol Chem
. 1999 Apr;
274(15):10388-94.
PMID: 10187828
The basis for impaired reduced folate carrier (RFC) activity in methotrexate-resistant CCRF-CEM (CEM/Mtx-1) cells was examined. Parental and CEM/Mtx-1 cells expressed identical levels of the 3. 1-kilobase RFC transcript. A...
2.
Wong S, Zhang L, Proefke S, Matherly L
Biochim Biophys Acta
. 1998 Oct;
1375(1-2):6-12.
PMID: 9767079
The role of N-glycosylation in reduced folate carrier (RFC) transport and membrane targeting was examined in transport-deficient K562 (K500E) cells transfected with human RFC cDNAs. Treatment of cells expressing wild-type...
3.
Wong S, Zhang L, Proefke S, Hukku B, Matherly L
Biochem Pharmacol
. 1998 May;
55(7):1135-8.
PMID: 9605439
The molecular bases for the 6-fold elevated methotrexate transport capacity of K562.4CF cells (Matherly et al., Cancer Res. 51: 3420-3426, 1991) were studied with reduced folate carrier (RFC) cDNA, genomic,...
4.
Wong S, McQuade R, Proefke S, Bhushan A, Matherly L
Biochem Pharmacol
. 1997 Jan;
53(2):199-206.
PMID: 9037252
A human reduced folate carrier (hRFC) cDNA was transfected into transport-deficient K562 cells to circumvent complications that may result from carrier expression in a heterologous mammalian species. Relative to wild-type...
5.
Wong S, Proefke S, Bhushan A, Matherly L
J Biol Chem
. 1995 Jul;
270(29):17468-75.
PMID: 7615551
This report describes the isolation, nucleotide sequencing, and functional expression of human cDNAs that restore reduced folate carrier activity in transport-defective cells. Based on homology to a partial murine cDNA...
6.
Matherly L, Taub J, Ravindranath Y, Proefke S, Wong S, Gimotty P, et al.
Blood
. 1995 Jan;
85(2):500-9.
PMID: 7812005
A retrospective study of clinical resistance to methotrexate (MTX) was performed on 29 archival specimens of frozen lymphoblasts obtained from children with acute lymphoblastic leukemia (ALL), including 19 at initial...