S A Osmani
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Explore the profile of S A Osmani including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Wu L, Osmani S, Mirabito P
J Cell Biol
. 1998 Jul;
141(7):1575-87.
PMID: 9647650
NIMA promotes entry into mitosis in late G2 by some mechanism that is after activation of the Aspergillus nidulans G2 cyclin-dependent kinase, NIMXCDC2/NIMECyclin B. Here we present two independent lines...
12.
Ye X, Fincher R, Tang A, McNeal K, Gygax S, Wexler A, et al.
J Biol Chem
. 1998 Jan;
272(52):33384-93.
PMID: 9407133
Previously, it has been shown that Aspergillus cells lacking the function of nimQ and the anaphase-promoting complex (APC) component bimEAPC1 enter mitosis without replicating DNA. Here nimQ is shown to...
13.
Renzi L, Gersch M, Campbell M, Wu L, Osmani S, Gorbsky G
J Cell Sci
. 1997 Oct;
110 ( Pt 17):2013-25.
PMID: 9378753
The MPM-2 antibody labels mitosis-specific and cell cycle-regulated phosphoproteins. The major phosphoproteins of mitotic chromosomes recognized by the MPM-2 antibody are DNA topoisomerase II (topoII) alpha and beta. In immunofluorescence...
14.
Osmani S, Ye X
Trends Cell Biol
. 1997 Jul;
7(7):283-8.
PMID: 17708961
Prevention of mitosis if DNA is damaged, or not fully replicated, is a widespread mechanism used by eukaryotic cells to maintain their ploidy and prevent accumulation of mutations. Such 'checkpoints'...
15.
Martin M, Osmani S, Oakley B
J Cell Sci
. 1997 Mar;
110 ( Pt 5):623-33.
PMID: 9092944
gamma-Tubulin has been hypothesized to be essential for the nucleation of the assembly of mitotic spindle microtubules, but some recent results suggest that this may not be the case. To...
16.
Ye X, Fincher R, Tang A, Osmani S
EMBO J
. 1997 Jan;
16(1):182-92.
PMID: 9009279
It is possible to cause G2 arrest in Aspergillus nidulans by inactivating either p34cdc2 or NIMA. We therefore investigated the negative control of these two mitosis-promoting kinases after DNA damage....
17.
Ye X, Osmani S
Prog Cell Cycle Res
. 1997 Jan;
3:221-32.
PMID: 9552417
In A. nidulans, activation of both p34cdc2/cyclinB H1 and NIMA kinases is required to initiate mitosis. These two kinases are regulated at several levels during interphase and are activated independently...
18.
Ye X, Xu G, Fincher R, Osmani S
Methods Enzymol
. 1997 Jan;
283:520-32.
PMID: 9251045
No abstract available.
19.
Osmani S, Ye X
Biochem J
. 1996 Aug;
317 ( Pt 3):633-41.
PMID: 8760343
Great progress has recently been made in our understanding of the regulation of the eukaryotic cell cycle, and the central role of cyclin-dependent kinases is now clear. In Aspergillus nidulans...
20.
Ye X, Fincher R, Tang A, ODonnell K, Osmani S
EMBO J
. 1996 Jul;
15(14):3599-610.
PMID: 8670863
We demonstrate that there are at least two S-phase checkpoint mechanisms controlling mitosis in Aspergillus. The first responds to the rate of DNA replication and inhibits mitosis via tyrosine phosphorylation...