S A Akman
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Explore the profile of S A Akman including associated specialties, affiliations and a list of published articles.
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54
Citations
340
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Recent Articles
1.
Chifman J, Kniss A, Neupane P, Williams I, Leung B, Deng Z, et al.
J Theor Biol
. 2012 Jan;
300:91-9.
PMID: 22286016
Iron is a metal essential for cellular metabolism. However, excess iron available for reactions contributes to the formation of dangerous reactive oxygen species, such as the hydroxyl radical, via the...
2.
Halicioglu O, Akman S, Sutcuoglu S, Coker I
Minerva Pediatr
. 2011 Jun;
63(3):169-75.
PMID: 21654597
Aim: Very little is known about the relationship between genotype and phenotype of cystic fibrosis (CF) from the Turkish children. The aim of the study was to analyze the genotype...
3.
Waters S, Akman S
Mutat Res
. 2001 Dec;
487(3-4):109-19.
PMID: 11738937
The double mismatch reversion (DMR) assay quantifies the repair of G:T mispairs exclusively by base excision repair in vivo. Synthetic oligonucleotides containing two G:T mispairs on opposite strands were placed...
4.
Aksoylar S, Akman S, Ozgenc F, Kansoy S
Pediatr Hematol Oncol
. 2001 Sep;
18(6):397-406.
PMID: 11554235
Tropisetron and granisetron are selective serotonin (5-HT3) antagonists that have been proven effective in the prevention of nausea and vomiting in adults and children receiving cancer chemotherapy. This prospective, randomised...
5.
Doroshow J, Synold T, Somlo G, Akman S, Gajewski E
Blood
. 2001 Apr;
97(9):2839-45.
PMID: 11313279
In prior studies, it was demonstrated that the redox metabolism of doxorubicin leads to the formation of promutagenic oxidized DNA bases in human chromatin, suggesting a potential mechanism for doxorubicin-related...
6.
Rodriguez H, Akman S, Holmquist G, Wilson G, Driggers W, LeDoux S
Methods
. 2000 Oct;
22(2):148-56.
PMID: 11020329
Reactive oxygen species induce a pharmacopoeia of oxidized bases in DNA. DNA can be cleaved at most of the sites of these modified bases by digestion with a combination of...
7.
Akman S, OConnor T, Rodriguez H
Ann N Y Acad Sci
. 2000 Jun;
899:88-102.
PMID: 10863531
We developed a method to map oxidative-induced DNA damage at the nucleotide level using ligation-mediated polymerase chain reaction (LMPCR) technology. In vivo and in vitro DNA base modification patterns inflicted...
8.
9.
Rodriguez H, Valentine M, Holmquist G, Akman S, Termini J
Biochemistry
. 1999 Dec;
38(50):16578-88.
PMID: 10600120
We have examined the DNA damage produced by reaction of peroxyl radicals with human fibroblast DNA. DNA damage consisted of both strand breaks and base modifications. The extent of strand...
10.
Rodriguez H, Akman S
Free Radic Res
. 1999 Mar;
29(6):499-510.
PMID: 10098455
DNA damage induced by reactive oxygen species (ROS) is considered an important intermediate in the pathogenesis of human conditions such as cancer and aging. By developing an oxidative-induced DNA damage...