Ryu Okumura
Overview
Explore the profile of Ryu Okumura including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1591
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Recent Articles
1.
Okumura R, Takeda K
Semin Immunopathol
. 2024 Nov;
47(1):2.
PMID: 39589551
In the intestinal tract, where numerous intestinal bacteria reside, intestinal epithelial cells produce and release various antimicrobial molecules that form a complex barrier on the mucosal surface. These barrier molecules...
2.
Horikiri M, Taniguchi M, Yoshikawa H, Okumura R, Matsuzaki T
Methods Mol Biol
. 2024 Feb;
2763:403-414.
PMID: 38347430
Mucus is part of the innate immune system that defends the mucosa against microbiota and other infectious threats. The mechanical characteristics of mucus, such as viscosity, elasticity, and lubricity, are...
3.
Okamoto S, Taniguchi M, Okumura R
Methods Mol Biol
. 2024 Feb;
2763:71-78.
PMID: 38347401
In the intestine, mucus covering the mucosa plays a critical role in maintaining gut homeostasis by protecting the mucosa from invasion by commensal bacteria. The gut mucus is composed primarily...
4.
Nakatani A, Okumura R, Ishibashi A, Okamoto S, Sakaki K, Ito Y, et al.
Genes Cells
. 2023 Sep;
28(11):776-788.
PMID: 37680073
In the intestine, interleukin (IL)-23 and IL-22 from immune cells in the lamina propria contribute to maintenance of the gut epithelial barrier through the induction of antimicrobial production and the...
5.
Taniguchi M, Okumura R, Matsuzaki T, Nakatani A, Sakaki K, Okamoto S, et al.
Mucosal Immunol
. 2023 Jun;
16(5):624-641.
PMID: 37385587
In the intestine, mucin 2 (Muc2) forms a network structure and prevents bacterial invasion. Glycans are indispensable for Muc2 barrier function. Among various glycosylation patterns of Muc2, sialylation inhibits bacteria-dependent...
6.
Chalalai T, Kamiyama N, Saechue B, Sachi N, Ozaka S, Ariki S, et al.
Biochem Biophys Res Commun
. 2023 Jun;
669:103-112.
PMID: 37269592
Tumor necrosis factor receptor-associated factor 6 (TRAF6) plays a pivotal role in the induction of inflammatory responses not only in innate immune cells but also in non-immune cells, leading to...
7.
Nii T, Maeda Y, Motooka D, Naito M, Matsumoto Y, Ogawa T, et al.
Ann Rheum Dis
. 2023 Jan;
82(5):621-629.
PMID: 36627170
Objectives: is considered to be a contributing factor in rheumatoid arthritis (RA). However, in some non-Westernised countries, healthy individuals also harbour an abundance of in the intestine. This study investigated...
8.
Matsuzaki T, Terutsuki D, Sato S, Ikarashi K, Sato K, Mitsuno H, et al.
J Phys Chem Lett
. 2022 Oct;
13(40):9494-9500.
PMID: 36201238
Cell-coupled field-effect transistor (FET) biosensors have attracted considerable attention because of their high sensitivity to biomolecules. The use of insect cells (Sf21) as a core sensor element is advantageous due...
9.
Nakagawa N, Hashii Y, Kayama H, Okumura R, Nakajima H, Minagawa H, et al.
Cancer Immunol Immunother
. 2022 Jun;
72(1):39-53.
PMID: 35699757
Wilms' tumor 1 (WT1) is a promising tumor-associated antigen for cancer immunotherapy. We developed an oral protein vaccine platform composed of WT1-anchored, genetically engineered Bifidobacterium longum (B. longum) and conducted...
10.
Liu Q, Umemoto E, Morita N, Kayama H, Baba Y, Kurosaki T, et al.
Int Immunol
. 2022 Mar;
34(7):343-352.
PMID: 35303081
CX3CR1high myeloid cells in the small intestine mediate the induction of oral tolerance by driving regulatory T (Treg) cells. Bacterial metabolites, e.g. pyruvate and lactate, induce a dendrite extension of...