Ryoichi Aki
Overview
Explore the profile of Ryoichi Aki including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
385
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Recent Articles
1.
Hasegawa-Haruki A, Obara K, Takaoka N, Shirai K, Hamada Y, Arakawa N, et al.
PLoS One
. 2024 Jun;
19(6):e0304676.
PMID: 38875234
Diabetes often results in chronic ulcers that fail to heal. Effective treatment for diabetic wounds has not been achieved, although stem-cell-treatment has shown promise. Hair-follicle-associated-pluripotent (HAP)-stem-cells from bulge area of...
2.
Takaoka N, Yamane M, Hasegawa A, Obara K, Shirai K, Aki R, et al.
PLoS One
. 2024 Jan;
19(1):e0297443.
PMID: 38277391
There has been only limited success to differentiate adult stem cells into cardiomyocyte subtypes. In the present study, we have successfully induced beating atrial and ventricular cardiomyocytes from rat hair-follicle-associated...
3.
Obara K, Shirai K, Hamada Y, Arakawa N, Hasegawa A, Takaoka N, et al.
PLoS One
. 2023 Jan;
18(1):e0280304.
PMID: 36638123
Intracerebral hemorrhage (ICH) is a leading cause of mortality with ineffective treatment. Hair-follicle-associated pluripotent (HAP) stem cells can differentiate into neurons, glial cells and many other types of cells. HAP...
4.
Takaoka N, Yamane M, Obara K, Shirai K, Aki R, Hamada Y, et al.
Med Mol Morphol
. 2022 May;
55(3):248-257.
PMID: 35536435
Cardiomyocytes have been differentiated from various stem cells such as human embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC), but it is difficult to produce mature cardiomyocytes. We...
5.
Obara K, Shirai K, Hamada Y, Arakawa N, Yamane M, Takaoka N, et al.
PLoS One
. 2022 Jan;
17(1):e0262755.
PMID: 35085322
Chronic spinal cord injury (SCI) is a highly debilitating and recalcitrant disease with limited treatment options. Although various stem cell types have shown some clinical efficacy for injury repair they...
6.
Yamane M, Takaoka N, Obara K, Shirai K, Aki R, Hamada Y, et al.
Cells
. 2021 Apr;
10(4).
PMID: 33920157
Hair-follicle-associated pluripotent (HAP) stem cells are located in the bulge area of hair follicles from mice and humans and have been shown to differentiate to neurons, glia, keratinocytes, smooth muscle...
7.
Shirai K, Obara K, Tohgi N, Yamazaki A, Aki R, Hamada Y, et al.
Tissue Cell
. 2019 Aug;
59:33-38.
PMID: 31383286
Hair-follicle-associated pluripotent (HAP) stem cells reside in the upper part of the bulge area of the the hair follicle. HAP stem cells are nestin-positive and keratin 15-negative and have the...
8.
Obara K, Tohgi N, Mii S, Hamada Y, Arakawa N, Aki R, et al.
Sci Rep
. 2019 Jun;
9(1):9326.
PMID: 31249324
The bulge area of the hair follicle contains hair-follicle-associated pluripotent (HAP) stem cells. Here, we present effective cryopreservation procedures of the human hair follicle that preserve the differentiation potential of...
9.
Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, Arakawa N, et al.
Stem Cell Rev Rep
. 2018 Oct;
15(1):59-66.
PMID: 30341634
Our previous studies showed that nestin-expressing hair follicle-associated-pluripotent (HAP) stem cells, which reside in the bulge area of the hair follicle, could restore injured nerve and spinal cord and differentiate...
10.
Yamazaki A, Obara K, Tohgi N, Shirai K, Mii S, Hamada Y, et al.
Cell Cycle
. 2017 Sep;
16(20):1927-1932.
PMID: 28886268
Hair follicle-associated-pluripotent (HAP) stem cells are located in the bulge area of the hair follicle, express the stem-cell marker, nestin, and have been shown to differentiate to nerve cells, glial...