Ryan L Kyle
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Explore the profile of Ryan L Kyle including associated specialties, affiliations and a list of published articles.
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11
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1244
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Recent Articles
1.
Leboit P, Patel D, Cohen J, Moss M, Naik H, Yates A, et al.
Exp Dermatol
. 2025 Feb;
34(2):e70057.
PMID: 39930604
Hidradenitis suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. Due to the relatively limited understanding of HS's pathogenesis, there are currently insufficient treatment options available, and...
2.
Kyle R, Prout M, Le Gros G, Robinson M
Immunol Cell Biol
. 2024 Jan;
102(3):194-211.
PMID: 38286436
T helper 2 (Th2) cells stochastically express from the Il4 locus but it has not been determined whether allelic expression is linked or independent. Here, we provide evidence that alleles...
3.
Edwards-Hicks J, Apostolova P, Buescher J, Maib H, Stanczak M, Corrado M, et al.
Nat Immunol
. 2023 Feb;
24(3):516-530.
PMID: 36732424
How lipidome changes support CD8 effector T (T) cell differentiation is not well understood. Here we show that, although naive T cells are rich in polyunsaturated phosphoinositides (PIP with 3-4...
4.
OSullivan D, Stanczak M, Villa M, Uhl F, Corrado M, Geltink R, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(25).
PMID: 34161266
Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show...
5.
Field C, Baixauli F, Kyle R, Puleston D, Cameron A, Sanin D, et al.
Cell Metab
. 2019 Dec;
31(2):422-437.e5.
PMID: 31883840
Regulatory T cells (Tregs) subdue immune responses. Central to Treg activation are changes in lipid metabolism that support their survival and function. Fatty acid binding proteins (FABPs) are a family...
6.
Puleston D, Buck M, Geltink R, Kyle R, Caputa G, OSullivan D, et al.
Cell Metab
. 2019 May;
30(2):352-363.e8.
PMID: 31130465
How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation...
7.
Qiu J, Villa M, Sanin D, Buck M, OSullivan D, Ching R, et al.
Cell Rep
. 2019 May;
27(7):2063-2074.e5.
PMID: 31091446
Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell...
8.
Cameron A, Castoldi A, Sanin D, Flachsmann L, Field C, Puleston D, et al.
Nat Immunol
. 2019 Mar;
20(4):420-432.
PMID: 30858618
The adoption of Warburg metabolism is critical for the activation of macrophages in response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme...
9.
Prout M, Kyle R, Ronchese F, Le Gros G
Front Immunol
. 2018 Jun;
9:1211.
PMID: 29910811
Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4's role in...
10.
Geltink R, Kyle R, Pearce E
Annu Rev Immunol
. 2018 Apr;
36:461-488.
PMID: 29677474
Metabolism drives function, on both an organismal and a cellular level. In T cell biology, metabolic remodeling is intrinsically linked to cellular development, activation, function, differentiation, and survival. After naive...