Ryan J Mailloux
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Explore the profile of Ryan J Mailloux including associated specialties, affiliations and a list of published articles.
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84
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2689
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Recent Articles
1.
Grayson C, Chalifoux O, Russo M, Avizonis D, Sterman S, Faerman B, et al.
Free Radic Biol Med
. 2024 Sep;
224:660-677.
PMID: 39278573
In the present study, we investigated the consequences of deleting the glutaredoxin-2 gene (Glrx2) on the development of non-alcoholic fatty liver disease (NAFLD) in male and female C57BL6N mice fed...
2.
Sies H, Mailloux R, Jakob U
Nat Rev Mol Cell Biol
. 2024 Jun;
25(9):758.
PMID: 38886589
No abstract available.
3.
Sies H, Mailloux R, Jakob U
Nat Rev Mol Cell Biol
. 2024 Apr;
25(9):701-719.
PMID: 38689066
Oxidation-reduction (redox) reactions are central to the existence of life. Reactive species of oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular processes. Yet, excessive...
4.
Mailloux R
Redox Biol
. 2024 Apr;
72:103155.
PMID: 38615490
The α-keto acid dehydrogenase complex (KDHc) class of mitochondrial enzymes is composed of four members: pyruvate dehydrogenase (PDHc), α-ketoglutarate dehydrogenase (KGDHc), branched-chain keto acid dehydrogenase (BCKDHc), and 2-oxoadipate dehydrogenase (OADHc)....
5.
Grayson C, Faerman B, Koufos O, Mailloux R
J Biol Chem
. 2024 Mar;
300(4):107159.
PMID: 38479602
In the present study, we examined the mitochondrial hydrogen peroxide (mHO) generating capacity of α-ketoglutarate dehydrogenase (KGDH) and compared it to components of the electron transport chain using liver mitochondria...
6.
Mailloux R
Biochim Biophys Acta Mol Cell Res
. 2023 Nov;
1871(2):119639.
PMID: 37996061
Redox realignment is integral to the initiation, progression, and metastasis of cancer. This requires considerable metabolic rewiring to induce aberrant shifts in redox homeostasis that favor high hydrogen peroxide (HO)...
7.
Chalifoux O, Faerman B, Mailloux R
J Biol Chem
. 2023 Oct;
299(12):105399.
PMID: 37898400
Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry points for monosaccharides and amino acids into the Krebs cycle and thus integral for mitochondrial bioenergetics. Both complexes produce mitochondrial...
8.
Mailloux R, Treberg J, Grayson C, Agellon L, Sies H
Nat Metab
. 2023 Aug;
5(10):1641.
PMID: 37605058
No abstract available.
9.
Grayson C, Mailloux R
Free Radic Biol Med
. 2023 Aug;
208:260-271.
PMID: 37573896
Mitochondria use hydrogen peroxide (HO) as a mitokine for cell communication. HO output for signaling depends on its rate of production and degradation, both of which are strongly affected by...
10.
Wang K, Moore A, Grayson C, Mailloux R
Free Radic Biol Med
. 2023 May;
204:287-300.
PMID: 37225107
Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital sources of hydrogen peroxide (HO) and key sites for redox regulation. Here, we report KGDH is more sensitive to inhibition by...