Ryan H Cunnington
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Explore the profile of Ryan H Cunnington including associated specialties, affiliations and a list of published articles.
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11
Citations
365
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Recent Articles
1.
Singh N, Cunnington R, Bhagirath A, Vaishampayan A, Khan M, Gupte T, et al.
iScience
. 2024 Dec;
27(12):111286.
PMID: 39628561
Cystic fibrosis (CF) is an autosomal recessive disease characterized by microbial infection and progressive decline in lung function, leading to significant morbidity and mortality. The bitter taste receptor T2R14 is...
2.
Kang S, Verma S, Hassanabad A, Teng G, Belke D, Dundas J, et al.
Can J Cardiol
. 2019 Dec;
36(4):543-553.
PMID: 31837891
Background: Empagliflozin, an SGLT2 inhibitor, has shown remarkable reductions in cardiovascular mortality and heart failure admissions (EMPA-REG OUTCOME). However, the mechanism underlying the heart failure protective effects of empagliflozin remains...
3.
Cunnington R, Northcott J, Ghavami S, Filomeno K, Jahan F, Kavosh M, et al.
J Cell Sci
. 2013 Oct;
127(Pt 1):40-9.
PMID: 24155330
Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion and proliferation but the mechanisms underlying this are poorly understood. Ski is a negative regulator of TGF-β-Smad signaling in myofibroblasts, and might redirect...
4.
Ghavami S, Cunnington R, Yeganeh B, Davies J, Rattan S, Bathe K, et al.
Biochim Biophys Acta
. 2012 Oct;
1823(12):2274-86.
PMID: 23026405
Trans fats are not a homogeneous group of molecules and less is known about the cellular effects of individual members of the group. Vaccenic acid (VA) and elaidic acid (EA)...
5.
6.
Cunnington R, Wang B, Ghavami S, Bathe K, Rattan S, Dixon I
Am J Physiol Cell Physiol
. 2010 Oct;
300(1):C176-86.
PMID: 20943957
Cardiac myofibroblasts are key players in chronic remodeling of the cardiac extracellular matrix, which is mediated in part by elevated transforming growth factor-β₁ (TGF-β₁). The c-Ski proto-oncoprotein has been shown...
7.
Santiago J, Dangerfield A, Rattan S, Bathe K, Cunnington R, Raizman J, et al.
Dev Dyn
. 2010 May;
239(6):1573-84.
PMID: 20503355
In fibrosing hearts, myofibroblasts are associated with cardiac extracellular matrix remodeling. Expression of key genes in the transition of cardiac fibroblast to myofibroblast phenotype in post-myocardial infarction heart and in...
8.
Cunnington R, Nazari M, Dixon I
Can J Physiol Pharmacol
. 2009 Nov;
87(10):764-72.
PMID: 19898560
Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production...
9.
Raizman J, Komljenovic J, Chang R, Deng C, Bedosky K, Rattan S, et al.
J Cell Physiol
. 2007 Jun;
213(2):540-51.
PMID: 17541957
Cardiac ventricular myofibroblast motility, proliferation, and contraction contribute to post-myocardial infarct wound healing, infarct scar formation, and remodeling of the ventricle remote to the site of infarction. The Na+-Ca2+ exchanger...
10.
Drobic V, Cunnington R, Bedosky K, Raizman J, Elimban V, Rattan S, et al.
Am J Physiol Heart Circ Physiol
. 2007 May;
293(2):H1053-64.
PMID: 17483238
Myofibroblasts respond to an array of signals from mitogens and cytokines during the course of wound healing following a myocardial infarction (MI), and these signals may coordinate ventricular myofibroblast proliferation....