Ryan Garrity
Overview
Explore the profile of Ryan Garrity including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
1064
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, et al.
Nat Metab
. 2024 Feb;
6(3):567-577.
PMID: 38378996
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole-body energy expenditure, counteracts obesity and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters that...
2.
Reddy A, Winther S, Tran N, Xiao H, Jakob J, Garrity R, et al.
bioRxiv
. 2023 Mar;
PMID: 36909624
Uptake of circulating succinate by brown adipose tissue (BAT) and beige fat elevates whole body energy expenditure, counteracts obesity, and antagonizes systemic tissue inflammation in mice. The plasma membrane transporters...
3.
Xiao H, Bozi L, Sun Y, Riley C, Philip V, Chen M, et al.
Cell
. 2022 Nov;
185(24):4654-4673.e28.
PMID: 36334589
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable...
4.
Bertholet A, Natale A, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, et al.
Nature
. 2022 May;
606(7912):180-187.
PMID: 35614225
Mitochondria generate heat due to H leak (I) across their inner membrane. I results from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat and...
5.
Mills E, Harmon C, Jedrychowski M, Xiao H, Gruszczyk A, Bradshaw G, et al.
Cell Metab
. 2021 Dec;
34(1):140-157.e8.
PMID: 34861155
Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss-of-function model has recently been shown to...
6.
Musunuru K, Chadwick A, Mizoguchi T, Garcia S, DeNizio J, Reiss C, et al.
Nature
. 2021 May;
593(7859):429-434.
PMID: 34012082
Gene-editing technologies, which include the CRISPR-Cas nucleases and CRISPR base editors, have the potential to permanently modify disease-causing genes in patients. The demonstration of durable editing in target organs of...
7.
Mills E, Harmon C, Jedrychowski M, Xiao H, Garrity R, Tran N, et al.
Nat Metab
. 2021 May;
3(5):604-617.
PMID: 34002097
Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD and is thought...
8.
Reddy A, Bozi L, Yaghi O, Mills E, Xiao H, Nicholson H, et al.
Cell
. 2020 Sep;
183(1):62-75.e17.
PMID: 32946811
In response to skeletal muscle contraction during exercise, paracrine factors coordinate tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing metabolite signal that initiates muscle remodeling upon...
9.
Jedrychowski M, Lu G, Szpyt J, Mariotti M, Garrity R, Paulo J, et al.
Proc Natl Acad Sci U S A
. 2020 May;
117(20):10789-10796.
PMID: 32358195
Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced reactivity with...
10.
Xiao H, Jedrychowski M, Schweppe D, Huttlin E, Yu Q, Heppner D, et al.
Cell
. 2020 Feb;
180(5):968-983.e24.
PMID: 32109415
Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a myriad of biological processes, but the...