Ruthann Nichols
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Explore the profile of Ruthann Nichols including associated specialties, affiliations and a list of published articles.
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22
Citations
192
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Recent Articles
1.
Nichols R, Bass C, Katanski C
Front Biosci (Landmark Ed)
. 2022 May;
27(5):150.
PMID: 35638417
Background: The structures and activities of invertebrate sulfakinins that influence gut motility and heart rate are like the vertebrate cholecystokinin (CCK) peptides. Typical of sulfakinin precursors encodes non-sulfated drosulfakinin I...
2.
Davis J, Chouman A, Creech J, Monteiro da Rocha A, Ponce-Balbuena D, Jimenez Vazquez E, et al.
JCI Insight
. 2021 Apr;
6(10).
PMID: 33878037
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been used extensively to model inherited heart diseases, but hiPSC-CM models of ischemic heart disease are lacking. Here, our objective was to...
3.
Leander M, Bass C, Marchetti K, Maynard B, Wulff J, Ons S, et al.
PLoS One
. 2015 Mar;
10(3):e0120492.
PMID: 25793503
Peptidergic signaling regulates cardiac contractility; thus, identifying molecular switches, ligand-receptor contacts, and antagonists aids in exploring the underlying mechanisms to influence health. Myosuppressin (MS), a decapeptide, diminishes cardiac contractility and...
4.
Maynard B, Bass C, Katanski C, Thakur K, Manoogian B, Leander M, et al.
PLoS One
. 2013 Sep;
8(9):e75502.
PMID: 24069424
FMRF-NH2 peptides which contain a conserved, identical C-terminal tetrapeptide but unique N terminus modulate cardiac contractility; yet, little is known about the mechanisms involved in signaling. Here, the structure-activity relationships...
5.
Nichols R, Bass C, Demers L, Larsen B, Li E, Blewett N, et al.
J Med Chem
. 2012 Aug;
55(17):7736-45.
PMID: 22909119
Human RFamide-related peptide-1 (hRFRP-1, MPHSFANLPLRF-NH(2)) binds to neuropeptide FF receptor 2 (NPFF(2)R) to dramatically diminish cardiovascular performance. hRFRP-1 and its signaling pathway may provide targets to address cardiac dysfunction. Here,...
6.
Nichols R, Manoogian B, Walling E, Mispelon M
Front Biosci (Landmark Ed)
. 2009 Mar;
14(11):4035-43.
PMID: 19273332
Neuropeptides regulate the frequency of heart contractions. Drosophila melanogaster sulfakinin (drosulfakinin) encodes FDDYGHMRFamide, DSK I, and GGDDQFDDYGHMRFamide, DSK II. Invertebrate sulfakinins are structurally and functionally related to vertebrate cholecystokinins. Naturally-occurring...
7.
Nichols R, Egle J, Langan N, Palmer G
Peptides
. 2008 Sep;
29(12):2128-35.
PMID: 18786583
Sulfakinins are myoactive peptides and antifeedant factors. Naturally occurring drosulfakinin I (DSK I; FDDYGHMRFNH(2)) and drosulfakinin II (DSK II; GGDDQFDDYGHMRFNH(2)) contain sulfated or nonsulfated tyrosine. We discovered sDSK II and...
8.
Palmer G, Tran T, Duttlinger A, Nichols R
J Insect Physiol
. 2007 Jul;
53(11):1125-33.
PMID: 17632121
We report that the drosulfakinin 0 (DSK 0; NQKTMSFNH2) structure and genomic organization are conserved. The DSK 0 C-terminus, SFNH2, is widely distributed in the animal kingdom suggesting it defines...
9.
Sohler S, Neupert S, Predel R, Nichols R, Stengl M
Cell Tissue Res
. 2007 Jan;
328(2):443-52.
PMID: 17216199
The myosuppressins (X1DVX2HX3FLRFamide), which reduce the frequency of insect muscle contractions, constitute a subgroup of the FMRFamide-related peptides. In the cockroach Leucophaea maderae, we have examined whether leucomyosuppressin (pQDVDHVFLRFamide) is...
10.
Angioy A, Muroni P, Tomassini Barbarossa I, McCormick J, Nichols R
Peptides
. 2006 Dec;
28(3):585-93.
PMID: 17141921
The molecular complexity of the simple blowfly heart makes it an attractive preparation to delineate cardiovascular mechanisms. Blowfly cardiac activity consists of a fast, high-frequency signal phase alternating with a...