Ruth Z Rutledge
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Explore the profile of Ruth Z Rutledge including associated specialties, affiliations and a list of published articles.
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12
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3282
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Recent Articles
1.
Garon E, Rizvi N, Hui R, Leighl N, Balmanoukian A, Eder J, et al.
N Engl J Med
. 2015 Apr;
372(21):2018-28.
PMID: 25891174
Background: We assessed the efficacy and safety of programmed cell death 1 (PD-1) inhibition with pembrolizumab in patients with advanced non-small-cell lung cancer enrolled in a phase 1 study. We...
2.
Blair Zartman C, Bell I, Gallicchio S, Graham S, Kane S, Mallee J, et al.
Bioorg Med Chem Lett
. 2011 Oct;
21(22):6705-8.
PMID: 21982500
Identification of an HIV integrase inhibitor with micromolar affinity for the CGRP receptor led to the discovery of a series of structurally novel CGRP receptor antagonists. Optimization of this series...
3.
Gilderman L, Lawless J, Nolen T, Sterling T, Rutledge R, Fernsler D, et al.
Clin Vaccine Immunol
. 2007 Dec;
15(2):314-9.
PMID: 18077611
The vaccine Zostavax has been shown to prevent herpes zoster (HZ) and postherpetic neuralgia and is recommended for individuals > or =60 years of age. This study compared the safety...
4.
Shaw A, Paone D, Nguyen D, Stump C, Burgey C, Mosser S, et al.
Bioorg Med Chem Lett
. 2007 Jul;
17(17):4795-8.
PMID: 17616394
Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Replacements for the benzodiazepine core of an earlier lead structure 1 including 5-, 6-, and 7-membered lactams were...
5.
Burgey C, Stump C, Nguyen D, Deng J, Quigley A, Norton B, et al.
Bioorg Med Chem Lett
. 2006 Aug;
16(19):5052-6.
PMID: 16889959
In our continuing effort to identify CGRP receptor antagonists for the acute treatment of migraine, we have undertaken a study to evaluate alternative 4-substituted piperidines to the lead dihydroquinazolinone 1....
6.
Williams T, Stump C, Nguyen D, Quigley A, Bell I, Gallicchio S, et al.
Bioorg Med Chem Lett
. 2006 Mar;
16(10):2595-8.
PMID: 16527483
High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists...
7.
Bilodeau M, Rodman L, McGaughey G, Coll K, Koester T, Hoffman W, et al.
Bioorg Med Chem Lett
. 2004 May;
14(11):2941-5.
PMID: 15125964
An azo-dye lead was modified to a novel N-(1,3-thiazol-2-yl)pyridin-2-amine series of KDR kinase inhibitors through the use of rapid analog libraries. This new class has been found to be potent,...
8.
Fraley M, Arrington K, Hambaugh S, Hoffman W, Cunningham A, Young M, et al.
Bioorg Med Chem Lett
. 2003 Aug;
13(18):2973-6.
PMID: 12941314
We have discovered 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as potent inhibitors of KDR kinase activity. This communication details the evolution of this novel class from a potent screening lead of vastly different structure with...
9.
Bilodeau M, Cunningham A, Koester T, Ciecko P, Coll K, Huckle W, et al.
Bioorg Med Chem Lett
. 2003 Jul;
13(15):2485-8.
PMID: 12852948
1,5-Diarylbenzimidazoles have been identified as potent inhibitors of KDR kinase activity. The series was developed with a goal of finding compounds with optimal drug-like properties. This communication describes structural modifications...
10.
Fraley M, Rubino R, Hoffman W, Hambaugh S, Arrington K, Hungate R, et al.
Bioorg Med Chem Lett
. 2002 Nov;
12(24):3537-41.
PMID: 12443771
We have introduced solubilizing functionality to a 3,6-disubstituted pyrazolo[1,5-a]pyrimidine series of KDR kinase inhibitors to improve the physical properties of these compounds. The addition of a basic side-chain to the...