Ruth Seggewiss
Overview
Explore the profile of Ruth Seggewiss including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
683
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Recent Articles
1.
Kreutzman A, Juvonen V, Kairisto V, Ekblom M, Stenke L, Seggewiss R, et al.
Blood
. 2010 Apr;
116(5):772-82.
PMID: 20413659
In a proportion of patients with chronic myeloid leukemia (CML) being treated with dasatinib, we recently observed large granular lymphocyte (LGL) expansions carrying clonal T-cell receptor (TCR) gamma/delta gene rearrangements....
2.
Seggewiss R, Einsele H
Blood
. 2010 Mar;
115(19):3861-8.
PMID: 20215642
Allogeneic hematopoietic stem cell transplantation (HSCT) has advanced to a common procedure for treating also older patients with malignancies and immunodeficiency disorders by redirecting the immune system. Unfortunately, cure is...
3.
Stuhmer T, Chatterjee M, Grella E, Seggewiss R, Langer C, Muller S, et al.
Br J Haematol
. 2009 Aug;
147(3):319-27.
PMID: 19686236
The 90 kD heat shock protein (Hsp90) molecular chaperone sustains multiple components of oncogenic pathways and has recently emerged as a therapeutic target that is now being clinically tested in...
4.
Lissina A, Ladell K, Skowera A, Clement M, Edwards E, Seggewiss R, et al.
J Immunol Methods
. 2008 Oct;
340(1):11-24.
PMID: 18929568
Flow cytometry with fluorochrome-conjugated peptide-major histocompatibility complex (pMHC) tetramers has transformed the study of antigen-specific T-cells by enabling their visualization, enumeration, phenotypic characterization and isolation from ex vivo samples. Here,...
5.
Weichsel R, Dix C, Wooldridge L, Clement M, Fenton-May A, Sewell A, et al.
Clin Cancer Res
. 2008 Apr;
14(8):2484-91.
PMID: 18413841
Purpose: The dual BCR-ABL/SRC kinase inhibitor dasatinib entered the clinic for the treatment of chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia. Because SRC kinases are known to play an...
6.
Seggewiss R, Einsele H
Semin Hematol
. 2007 Jul;
44(3):203-11.
PMID: 17631184
The aim of hematopoietic stem cell transplantation (HSCT) is to cure patients of malignancies, autoimmune diseases, and immunodeficiency disorders by redirecting the immune system: the often described graft-versus-leukemia (GVL) or...
7.
Leder C, Ortler S, Seggewiss R, Einsele H, Wiendl H
Exp Hematol
. 2007 Jun;
35(8):1266-71.
PMID: 17560008
Objective: Recently, evidence was provided, that the selective tyrosine kinase inhibitor imatinib mesylate (imatinib) has immunomodulatory or suppressive effects. However, the discussion about imatinib's influence on immune cells is still...
8.
Shepherd B, Kiem H, Lansdorp P, Dunbar C, Aubert G, Larochelle A, et al.
Blood
. 2007 May;
110(6):1806-13.
PMID: 17526860
Little is known about the behavior of hematopoietic stem cells (HSCs) in primates because direct observations and competitive-repopulation assays are not feasible. Therefore, we used 2 different and independent experimental...
9.
Seggewiss R, Lore K, Guenaga F, Pittaluga S, Mattapallil J, Chow C, et al.
Blood
. 2007 Mar;
110(1):441-9.
PMID: 17374737
Opportunistic infections contribute to morbidity and mortality after peripheral blood progenitor cell (PBPC) transplantation and are related to a deficient T-cell compartment. Accelerated T-cell reconstitution may therefore be clinically beneficent....
10.
Lore K, Seggewiss R, Guenaga F, Pittaluga S, Donahue R, Krouse A, et al.
Stem Cells
. 2006 Feb;
24(6):1539-48.
PMID: 16497945
Immunodeficiency after peripheral blood progenitor cell (PBPC) transplantation may be influenced by graft composition, underlying disease, and/or pre-treatment. These factors are difficult to study independently in humans. Ex vivo culture...