Russell J Thomas
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Explore the profile of Russell J Thomas including associated specialties, affiliations and a list of published articles.
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7
Citations
209
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Recent Articles
1.
Tobik E, Kitfield-Vernon L, Thomas R, Steel S, Tan S, Allicock O, et al.
Expert Rev Mol Diagn
. 2022 Jun;
22(5):519-535.
PMID: 35763281
Introduction: Symptomatic testing and asymptomatic screening for SARS-CoV-2 continue to be essential tools for mitigating virus transmission. Though COVID-19 diagnostics initially defaulted to oropharyngeal or nasopharyngeal sampling, the worldwide urgency...
2.
Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway
Del Bello F, Farande A, Giannella M, Piergentili A, Quaglia W, Benicchi T, et al.
Bioorg Med Chem
. 2015 Aug;
23(17):5725-33.
PMID: 26233797
The canonical Wnt signaling pathway plays a fundamental role in embryonic as well as in adult development. Consequently, dysregulation of the pathway has been linked to a wide spectrum of...
3.
Del Bello F, Mattioli L, Ghelfi F, Giannella M, Piergentili A, Quaglia W, et al.
J Med Chem
. 2010 Oct;
53(21):7825-35.
PMID: 20925410
The functional in vitro study of the enantiomers of imidazolines 4-7 highlighted the role played by the nature of the ortho phenyl substituent in determining the preferred α(2C)-AR configuration. Indeed,...
4.
Napper A, Hixon J, McDonagh T, Keavey K, Pons J, Barker J, et al.
J Med Chem
. 2005 Dec;
48(25):8045-54.
PMID: 16335928
High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processing enzymes....
5.
Quattropani A, Dorbais J, Covini D, Pittet P, Colovray V, Thomas R, et al.
J Med Chem
. 2005 Nov;
48(24):7882-905.
PMID: 16302826
We report a novel chemical class of potent oxytocin receptor antagonists showing a high degree of selectivity against the closely related vasopressin receptors (V1a, V1b, V2). An initial compound, 7,...
6.
Ashton M, Charlton M, Schwarz M, Thomas R, Whittaker M
Comb Chem High Throughput Screen
. 2004 Aug;
7(5):441-52.
PMID: 15320711
Virtual screening methods using structure-based, pharmacophore-based and descriptor based protocols may be used to identify ligands for the G-protein coupled receptor target family. A complementary approach is the synthesis and...
7.
Cirillo R, Gillio Tos E, Schwarz M, Quattropani A, Scheer A, Missotten M, et al.
J Pharmacol Exp Ther
. 2003 Mar;
306(1):253-61.
PMID: 12660315
We have discovered a new, potent, selective, and orally active oxytocin receptor antagonist, (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide (compound 1). We report the biochemical, pharmacological, and pharmacokinetic characterization in vitro and in vivo of...