Ruopeng Feng
Overview
Explore the profile of Ruopeng Feng including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
502
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0
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Recent Articles
1.
Yang X, Cheng L, Xin Y, Zhang J, Chen X, Xu J, et al.
Genome Biol
. 2025 Feb;
26(1):44.
PMID: 40022213
Background: CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not been extensively investigated. Results: Using...
2.
Jang Y, Feng R, Palmer L, Mayuranathan T, Yao Y, Mayberry K, et al.
Blood Adv
. 2025 Feb;
PMID: 40020162
Genetic depletion of the transcriptional repressor BCL11A in red blood cell precursors alleviates b-hemoglobinopathies by inducing the fetal g-globin genes. However, additional erythroid genes are regulated by BCL11A and the...
3.
Bloom M, Oak N, Baskin-Doerfler R, Feng R, Iacobucci I, Baviskar P, et al.
Blood Adv
. 2023 Jul;
7(18):5608-5623.
PMID: 37522715
ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in hematopoietic stem and progenitor cells (HSPCs), where it is required for adult hematopoiesis. Heterozygous pathogenic germline ETV6 variants are associated...
4.
Mayuranathan T, Newby G, Feng R, Yao Y, Mayberry K, Lazzarotto C, et al.
Nat Genet
. 2023 Jul;
55(7):1210-1220.
PMID: 37400614
Inducing fetal hemoglobin (HbF) in red blood cells can alleviate β-thalassemia and sickle cell disease. We compared five strategies in CD34 hematopoietic stem and progenitor cells, using either Cas9 nuclease...
5.
Feng R, Mayuranathan T, Huang P, Doerfler P, Li Y, Yao Y, et al.
Nature
. 2022 Oct;
610(7933):783-790.
PMID: 36224385
Around birth, globin expression in human red blood cells (RBCs) shifts from γ-globin to β-globin, which results in fetal haemoglobin (HbF, αγ) being gradually replaced by adult haemoglobin (HbA, αβ)....
6.
Qin K, Huang P, Feng R, Keller C, Peslak S, Khandros E, et al.
Nat Genet
. 2022 Jun;
54(6):906.
PMID: 35650318
No abstract available.
7.
Qin K, Huang P, Feng R, Keller C, Peslak S, Khandros E, et al.
Nat Genet
. 2022 May;
54(6):874-884.
PMID: 35618846
The mechanisms by which the fetal-type β-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental question in human biology and have therapeutic relevance to...
8.
Topfer S, Feng R, Huang P, Ly L, Martyn G, Blobel G, et al.
Blood
. 2022 Jan;
139(14):2107-2118.
PMID: 35090172
The benign condition hereditary persistence of fetal hemoglobin (HPFH) is known to ameliorate symptoms of co-inherited β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. The condition is sometimes associated with...
9.
SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Polyanskaya S, Moreno R, Lu B, Feng R, Yao Y, Irani S, et al.
Cell Rep
. 2022 Jan;
38(2):110233.
PMID: 35021089
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we use domain-focused CRISPR screening and identify the nuclear phosphatase SCP4 as a dependency in...
10.
Doerfler P, Feng R, Li Y, Palmer L, Porter S, Bell H, et al.
Nat Genet
. 2021 Aug;
53(8):1177-1186.
PMID: 34341563
Hereditary persistence of fetal hemoglobin (HPFH) ameliorates β-hemoglobinopathies by inhibiting the developmental switch from γ-globin (HBG1/HBG2) to β-globin (HBB) gene expression. Some forms of HPFH are associated with γ-globin promoter...