Ruensern Tan
Overview
Explore the profile of Ruensern Tan including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
245
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Recent Articles
1.
McSwiggen D, Liu H, Tan R, Agramunt Puig S, Akella L, Berman R, et al.
Elife
. 2025 Jan;
12.
PMID: 39786807
The regulation of cell physiology depends largely upon interactions of functionally distinct proteins and cellular components. These interactions may be transient or long-lived, but often affect protein motion. Measurement of...
2.
Siahaan V, Tan R, Humhalova T, Libusova L, Lacey S, Tan T, et al.
Nat Chem Biol
. 2022 Aug;
18(11):1224-1235.
PMID: 35996000
Tau is an intrinsically disordered microtubule-associated protein (MAP) implicated in neurodegenerative disease. On microtubules, tau molecules segregate into two kinetically distinct phases, consisting of either independently diffusing molecules or interacting...
3.
Canty J, Tan R, Kusakci E, Fernandes J, Yildiz A
Annu Rev Biophys
. 2021 May;
50:549-574.
PMID: 33957056
Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules. Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells and mediating spindle...
4.
Tan R, Lam A, Tan T, Han J, Nowakowski D, Vershinin M, et al.
Nat Cell Biol
. 2019 Sep;
21(9):1078-1085.
PMID: 31481790
Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the physiological state of tau...
5.
Charafeddine R, Cortopassi W, Lak P, Tan R, McKenney R, Jacobson M, et al.
J Biol Chem
. 2019 Apr;
294(22):8779-8790.
PMID: 30992364
Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and organizes axonal microtubules in healthy neurons. In neurodegenerative tauopathies, tau dissociates from microtubules and forms neurotoxic extracellular aggregates....
6.
Tan R, Foster P, Needleman D, McKenney R
Dev Cell
. 2018 Feb;
44(2):233-247.e4.
PMID: 29401420
Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions...
7.
Wang Q, Liu Y, Fu Q, Xu B, Zhang Y, Kim S, et al.
Circulation
. 2016 Nov;
135(1):73-88.
PMID: 27815373
Background: Type 2 diabetes mellitus (DM) and obesity independently increase the risk of heart failure by incompletely understood mechanisms. We propose that hyperinsulinemia might promote adverse consequences in the hearts...