Rudolf Fuchshofer
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Explore the profile of Rudolf Fuchshofer including associated specialties, affiliations and a list of published articles.
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66
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2055
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Recent Articles
1.
Acott T, Fautsch M, Mao W, Ethier C, Huang A, Kelley M, et al.
Invest Ophthalmol Vis Sci
. 2024 Dec;
65(14):32.
PMID: 39693082
Intraocular pressure (IOP) elevation is the primary risk factor and currently the main treatable factor for progression of glaucomatous optic neuropathy. In addition to direct clinical and living animal in...
2.
Reinehr S, Rahim Pamuk M, Fuchshofer R, Dick H, Joachim S
Neurobiol Aging
. 2024 Oct;
145:55-64.
PMID: 39481321
Besides an elevated intraocular pressure (IOP), advanced age is one of the most crucial risk factors for developing glaucoma. βB1-Connective Tissue Growth Factor (βB1-CTGF) high-pressure glaucoma mice were used in...
3.
Reinehr S, Wulf J, Theile J, Schulte K, Peters M, Fuchshofer R, et al.
Front Immunol
. 2024 Mar;
15:1296178.
PMID: 38515755
Background: The neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model,...
4.
Dillinger A, Kuespert S, Seleem A, Neuendorf J, Schneider M, Fuchshofer R
Front Mol Biosci
. 2023 May;
10:1045411.
PMID: 37251082
TGF-β2 is the predominant TGF-β isoform within the eye. One function of TGF-β2 is to provide the eye with immune protection against intraocular inflammation. The beneficial function of TGF-β2 within...
5.
Reinehr S, Girbig R, Schulte K, Theile J, Asaad M, Fuchshofer R, et al.
Front Immunol
. 2023 Feb;
13:1017076.
PMID: 36733392
Introduction: Glaucoma is a complex, multifactorial neurodegenerative disease, which can lead to blindness if left untreated. It seems that, among others, immune processes, elevated intraocular pressure (IOP), or a combination...
6.
Dillinger A, Weber G, Mayer M, Schneider M, Goppner C, Ohlmann A, et al.
Front Cell Dev Biol
. 2022 May;
10:864433.
PMID: 35493079
In primary open-angle glaucoma (POAG), a neurodegenerative disease of the optic nerve (ON) and leading cause of blindness, the optic nerve head (ONH) undergoes marked structural extracellular matrix (ECM) changes,...
7.
McDowell C, Kizhatil K, Elliott M, Overby D, van Batenburg-Sherwood J, Millar J, et al.
Invest Ophthalmol Vis Sci
. 2022 Feb;
63(2):12.
PMID: 35129590
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular...
8.
Mietzner R, Pawlak R, Tamm E, Goepferich A, Fuchshofer R, Breunig M
Pharmaceuticals (Basel)
. 2022 Jan;
15(1).
PMID: 35056075
A root cause for the development and progression of primary open-angle glaucoma might be the loss of the Schlemm's canal (SC) cell function due to an impaired Angiopoietin-1 (Angpt-1)/Tie2 signaling....
9.
Reinehr S, Doerner J, Mueller-Buehl A, Koch D, Fuchshofer R, Dick H, et al.
Front Cell Neurosci
. 2021 Dec;
15:718087.
PMID: 34867198
Glaucoma is a complex neurodegenerative disease leading to a loss of retinal ganglion cells (RGCs) and optic nerve axons. An activation of the complement system seems to contribute to cell...
10.
Schneider M, Dillinger A, Ohlmann A, Iozzo R, Fuchshofer R
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34299278
During the pathogenesis of glaucoma, optic nerve (ON) axons become continuously damaged at the optic nerve head (ONH). This often is associated with reactive astrocytes and increased transforming growth factor...