Ruben Gutierrez-Sagal
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Explore the profile of Ruben Gutierrez-Sagal including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Ulloa-Aguirre A, Anderson R, Zarinan T, Gutierrez-Sagal R, Jardon-Valadez E, Newton C
Andrology
. 2025 Mar;
PMID: 40052453
Background: G protein-coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein-coupled receptors need to be...
2.
Zarinan T, Espinal-Enriquez J, Anda-Jauregui G, Lira-Albarran S, Hernandez-Montes G, Gutierrez-Sagal R, et al.
PLoS One
. 2024 Jun;
19(6):e0293688.
PMID: 38843139
It has been documented that variations in glycosylation on glycoprotein hormones, confer distinctly different biological features to the corresponding glycoforms when multiple in vitro biochemical readings are analyzed. We here...
3.
Cruz-Huerta E, Zarinan T, Enriquez J, Ulloa-Aguirre A, Gutierrez-Sagal R
Gen Comp Endocrinol
. 2023 Dec;
347:114424.
PMID: 38101487
To study the estrogen regulated transcription of the uteroglobin (UG) gene, the founding member of the secretoglobin family widely expressed in many different mammalian species, we re-created functional estrogen response...
4.
Zarinan T, Espinal-Enriquez J, Anda-Jauregui G, Lira-Albarran S, Hernandez-Montes G, Gutierrez-Sagal R, et al.
bioRxiv
. 2023 Oct;
PMID: 37905087
It has been documented that variations in glycosylation on glycoprotein hormones, confer distinctly different biological features to the corresponding glycoforms when multiple biochemical readings are analyzed. We here applied next...
5.
Ulloa-Aguirre A, Zarinan T, Gutierrez-Sagal R, Tao Y
Front Endocrinol (Lausanne)
. 2022 Sep;
13:934685.
PMID: 36093106
G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an array of functions. Mutations in these receptors lead to a number of genetic diseases, including diseases involving the endocrine...
6.
Flores-Ramirez I, Rivas-Torres M, Rodriguez-Dorantes M, Gutierrez-Sagal R, Baranda-Avila N, Langley E
J Steroid Biochem Mol Biol
. 2021 Mar;
210:105858.
PMID: 33647521
Coregulators play an important role in prostate cancer (PCa), modulating androgen receptor (AR) action and representing a possible cause of androgen deprivation therapy failure. Pin2-interacting protein X1 (PinX1) is a...
7.
Zarinan T, Mayorga J, Jardon-Valadez E, Gutierrez-Sagal R, Maravillas-Montero J, Mejia-Dominguez N, et al.
J Clin Endocrinol Metab
. 2020 Oct;
106(2):e534-e550.
PMID: 33119067
Context: Follicle-stimulating hormone (FSH) plays an essential role in gonadal function. Loss-of-function mutations in the follicle-stimulating hormone receptor (FSHR) are an infrequent cause of primary ovarian failure. Objective: To analyze...
8.
Zarinan T, Butnev V, Gutierrez-Sagal R, Maravillas-Montero J, Martinez-Luis I, Mejia-Dominguez N, et al.
J Endocr Soc
. 2020 Apr;
4(5):bvaa019.
PMID: 32342021
FSH exists as different glycoforms that differ in glycosylation of the hormone-specific β-subunit. Tetra-glycosylated FSH (FSH) and hypo-glycosylated FSH (FSH) are the most abundant glycoforms found in humans. Employing distinct...
9.
Ulloa-Aguirre A, Zarinan T, Jardon-Valadez E, Gutierrez-Sagal R, Dias J
Front Endocrinol (Lausanne)
. 2018 Dec;
9:707.
PMID: 30555414
The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This structurally complex receptor is a member of the G-protein coupled receptor (GPCR) superfamily of membrane receptors. As with...
10.
Jardon-Valadez E, Castillo-Guajardo D, Martinez-Luis I, Gutierrez-Sagal R, Zarinan T, Ulloa-Aguirre A
PLoS One
. 2018 Nov;
13(11):e0207526.
PMID: 30462715
Follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) and a prototype of the glycoprotein hormone receptors subfamily of GPCRs. Structural data of the FSHR ectodomain in complex with...