George R Bousfield
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Explore the profile of George R Bousfield including associated specialties, affiliations and a list of published articles.
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37
Citations
562
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Recent Articles
1.
Ulloa-Aguirre A, Zarinan T, Dias J, Kumar T, Bousfield G
Pharmacol Ther
. 2025 Feb;
268:108821.
PMID: 39961417
Follicle-stimulating hormone (FSH) or follitropin plays a fundamental role in several mammalian species, including humans. This gonadotropin is produced by the anterior pituitary gland and has as its main targets...
2.
Zarinan T, Espinal-Enriquez J, Anda-Jauregui G, Lira-Albarran S, Hernandez-Montes G, Gutierrez-Sagal R, et al.
PLoS One
. 2024 Jun;
19(6):e0293688.
PMID: 38843139
It has been documented that variations in glycosylation on glycoprotein hormones, confer distinctly different biological features to the corresponding glycoforms when multiple in vitro biochemical readings are analyzed. We here...
3.
Zarinan T, Espinal-Enriquez J, Anda-Jauregui G, Lira-Albarran S, Hernandez-Montes G, Gutierrez-Sagal R, et al.
bioRxiv
. 2023 Oct;
PMID: 37905087
It has been documented that variations in glycosylation on glycoprotein hormones, confer distinctly different biological features to the corresponding glycoforms when multiple biochemical readings are analyzed. We here applied next...
4.
Converse A, Liu Z, Patel J, Shakyawar S, Guda C, Bousfield G, et al.
Development
. 2023 Oct;
150(22).
PMID: 37870089
Macroheterogeneity in follicle-stimulating hormone (FSH) β-subunit N-glycosylation results in distinct FSH glycoforms. Hypoglycosylated FSH21 is the abundant and more bioactive form in pituitaries of females under 35 years of age,...
5.
Lispi M, Humaidan P, Bousfield G, DHooghe T, Ulloa-Aguirre A
Int J Mol Sci
. 2023 May;
24(10).
PMID: 37240364
Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining...
6.
Butnev V, May J, Brown A, Sharma T, Butnev V, White W, et al.
Front Endocrinol (Lausanne)
. 2022 Nov;
13:767661.
PMID: 36329887
Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans. The two most...
7.
Johnson G, Onabanjo C, Hardy K, Butnev V, Bousfield G, Jonas K
Endocrinology
. 2022 Oct;
163(12).
PMID: 36201606
Follicle-stimulating hormone (FSH) is a key endocrine regulator of ovarian function. FSH is secreted as 2 macroglycosylation variants: partially glycosylated FSH (FSH21/18) and fully glycosylated FSH (FSH24). FSH21/18 is more...
8.
Agwuegbo U, Colley E, Albert A, Butnev V, Bousfield G, Jonas K
Front Endocrinol (Lausanne)
. 2021 Dec;
12:765727.
PMID: 34925235
Follicle-stimulating hormone (FSH) and its target G protein-coupled receptor (FSHR) are essential for reproduction. Recent studies have established that the hypo-glycosylated pituitary FSH glycoform (FSH21/18), is more bioactive and than...
9.
Hua G, George J, Clark K, Jonas K, Johnson G, Southekal S, et al.
Hum Reprod
. 2021 Jun;
36(7):1891-1906.
PMID: 34059912
Study Question: Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? Summary Answer: Compared with...
10.
Althumairy D, Zhang X, Baez N, Barisas G, Roess D, Bousfield G, et al.
Diseases
. 2020 Sep;
8(3).
PMID: 32942611
Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings. Both receptors and the thyroid-stimulating hormone receptor are members...