Roulin Chen
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Explore the profile of Roulin Chen including associated specialties, affiliations and a list of published articles.
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9
Citations
15
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Recent Articles
1.
Du Z, Zhu Y, Lu Z, Chen R, Huang Z, Chen Y, et al.
J Agric Food Chem
. 2024 Jun;
72(25):14191-14198.
PMID: 38878091
3-Fucosyllactose (3-FL), an important fucosylated human milk oligosaccharide in breast milk, offers numerous health benefits to infants. Previously, we metabolically engineered BL21(DE3) for the biosynthesis of 3-FL. In this study,...
2.
Zhu Y, Chen R, Wang H, Chen Y, Huang Z, Du Z, et al.
J Agric Food Chem
. 2024 Apr;
PMID: 38598361
Difucosyllactose (DFL) is a significant and plentiful oligosaccharide found in human breast milk. In this study, an artificial metabolic pathway of DFL was designed, focusing on the de novo biosynthesis...
3.
Chen R, Zhu Y, Wang H, Liu Y, Meng J, Chen Y, et al.
J Agric Food Chem
. 2023 Sep;
71(40):14678-14686.
PMID: 37773050
2'-Fucosyllactose (2'-FL), the most typical human milk oligosaccharide, is used as an additive in premium infant formula. Herein, we constructed two highly effective 2'-FL synthesis producers a GDP-fucose pathway from...
4.
Zhu Y, Chen R, Wang H, Chen Y, Liu Y, Zhou J, et al.
J Agric Food Chem
. 2023 Mar;
71(12):4915-4923.
PMID: 36876899
2'-Fucosyllactose (2'-FL) is a kind of fucosylated human milk oligosaccharide (HMO), representing the most abundant oligosaccharide in breast milk. We conducted systematic studies on three canonical α1,2-fucosyltransferases (WbgL, FucT2, and...
5.
Chen Y, Zhu Y, Wang H, Chen R, Liu Y, Zhang W, et al.
Bioresour Technol
. 2023 Mar;
374:128818.
PMID: 36868425
Human milk oligosaccharides are complex, indigestible oligosaccharides that provide ideal nutrition for infant development. Here, 2'-fucosyllactose was efficiently produced in Escherichia coli by using a biosynthetic pathway. For this, both...
6.
Meng J, Zhu Y, Chen R, Liu Y, Zhang W, Mu W
J Agric Food Chem
. 2023 Jan;
71(5):2464-2471.
PMID: 36700831
l-Fucose is a natural deoxy hexose found in a variety of organisms. It possesses many physiological effects and has potential applications in pharmaceutical, cosmetic, and food industries. Microbial synthesis via...
7.
Chen R, Wan L, Zhu Y, Liu Y, Zhang W, Mu W
Biotechnol Bioeng
. 2022 Nov;
120(2):524-535.
PMID: 36326175
As one of the most abundant components in human milk oligosaccharides, 2'-fucosyllactose (2'-FL) possesses versatile beneficial health effects. Although most studies focused on overexpressing or fine-tuning the expression of pathway...
8.
Wan L, Chen R, Zhu Y, Zhang W, Mu W
ACS Synth Biol
. 2022 Oct;
11(10):3154-3162.
PMID: 36197832
Nature is enriched with specific interactions between receptor proteins and their cognate ligands. These interacting pairs can be exploited and applied for the construction of well-ordered multicomponent assemblies with multivalency...
9.
Liu Y, Zhu Y, Wan L, Chen R, Zhang W, Mu W
J Agric Food Chem
. 2022 Jul;
70(29):9017-9025.
PMID: 35834320
2'-Fucosyllactose (2'-FL) is the most abundant oligosaccharide in human milk. In this study, a highly efficient biosynthetic route for 2'-FL production was designed the pathway of GDP-l-fucose using engineered BL21(DE3)....