Ross N Chapman
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Explore the profile of Ross N Chapman including associated specialties, affiliations and a list of published articles.
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4
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174
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Recent Articles
1.
Henchey L, Kushal S, Dubey R, Chapman R, Olenyuk B, Arora P
J Am Chem Soc
. 2010 Jan;
132(3):941-3.
PMID: 20041650
Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for genomic research and, potentially, drug discovery efforts for the treatment of neovascularization in cancers. We report a stabilized...
2.
Chapman R, Arora P
Org Lett
. 2006 Dec;
8(25):5825-8.
PMID: 17134282
This manuscript discusses microwave-assisted solid-phase synthesis of hydrogen-bond surrogate based alpha-helices and analogues by ring-closing metathesis (RCM). Microwave-mediated RCM allows access to a greater variety of amino acid residues in...
3.
Dimartino G, Wang D, Chapman R, Arora P
Org Lett
. 2005 Jun;
7(12):2389-92.
PMID: 15932205
[reaction: see text] This report describes the solid-phase synthesis of hydrogen-bond surrogate-derived artificial alpha-helices by a ring-closing metathesis reaction. From a series of metathesis catalysts evaluated for the synthesis of...
4.
Chapman R, Dimartino G, Arora P
J Am Chem Soc
. 2004 Sep;
126(39):12252-3.
PMID: 15453743
Herein we describe a strategy for the preparation of artificial alpha-helices involving replacement of one of the main-chain hydrogen bonds with a covalent linkage. To mimic the C=O...H-N hydrogen bond...