Ross C McKiernan
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Explore the profile of Ross C McKiernan including associated specialties, affiliations and a list of published articles.
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9
Citations
735
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Recent Articles
1.
Reynolds J, Miller-Delaney S, Jimenez-Mateos E, Sano T, McKiernan R, Simon R, et al.
Front Neurol
. 2015 Mar;
6:46.
PMID: 25806020
Exposure of the brain to brief, non-harmful seizures can activate protective mechanisms that temporarily generate a damage-refractory state. This process, termed epileptic tolerance, is associated with large-scale down-regulation of gene...
2.
Miller-Delaney S, Bryan K, Das S, McKiernan R, Bray I, Reynolds J, et al.
Brain
. 2015 Jan;
138(Pt 3):616-31.
PMID: 25552301
Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to explain the sustained hyperexcitability of chronic epilepsy....
3.
Jimenez-Mateos E, Engel T, Merino-Serrais P, Fernaud-Espinosa I, Rodriguez-Alvarez N, Reynolds J, et al.
Brain Struct Funct
. 2014 May;
220(4):2387-99.
PMID: 24874920
Emerging data support roles for microRNA (miRNA) in the pathogenesis of various neurologic disorders including epilepsy. MicroRNA-134 (miR-134) is enriched in dendrites of hippocampal neurons, where it negatively regulates spine...
4.
Brennan G, Jimenez-Mateos E, McKiernan R, Engel T, Tzivion G, Henshall D
PLoS One
. 2013 Jan;
8(1):e54491.
PMID: 23359526
14-3-3 proteins are ubiquitous molecular chaperones that are abundantly expressed in the brain where they regulate cell functions including metabolism, the cell cycle and apoptosis. Brain levels of several 14-3-3...
5.
McKiernan R, Jimenez-Mateos E, Sano T, Bray I, Stallings R, Simon R, et al.
Exp Neurol
. 2012 Jul;
237(2):346-54.
PMID: 22771761
Brief seizures (epileptic/seizure preconditioning) are capable of activating endogenous protective pathways in the brain which can temporarily generate a damage-refractory state against subsequent and otherwise harmful episodes of prolonged seizures...
6.
Jimenez-Mateos E, Engel T, Merino-Serrais P, McKiernan R, Tanaka K, Mouri G, et al.
Nat Med
. 2012 Jun;
18(7):1087-94.
PMID: 22683779
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate post-transcriptional expression of protein-coding mRNAs, which may have...
7.
McKiernan R, Jimenez-Mateos E, Bray I, Engel T, Brennan G, Sano T, et al.
PLoS One
. 2012 May;
7(5):e35921.
PMID: 22615744
Hippocampal sclerosis (HS) is a common pathological finding in patients with temporal lobe epilepsy (TLE) and is associated with altered expression of genes controlling neuronal excitability, glial function, neuroinflammation and...
8.
Jimenez-Mateos E, Bray I, Sanz-Rodriguez A, Engel T, McKiernan R, Mouri G, et al.
Am J Pathol
. 2011 Sep;
179(5):2519-32.
PMID: 21945804
When an otherwise harmful insult to the brain is preceded by a brief, noninjurious stimulus, the brain becomes tolerant, and the resulting damage is reduced. Epileptic tolerance develops when brief...
9.
Haugh M, Murphy C, McKiernan R, Altenbuchner C, OBrien F
Tissue Eng Part A
. 2010 Dec;
17(9-10):1201-8.
PMID: 21155630
Crosslinking and the resultant changes in mechanical properties have been shown to influence cellular activity within collagen biomaterials. With this in mind, we sought to determine the effects of crosslinking...