Rosario D C Hirata
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Explore the profile of Rosario D C Hirata including associated specialties, affiliations and a list of published articles.
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59
Citations
547
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Recent Articles
1.
de Melo T, de Souza K, Ururahy M, Bortolin R, Bezerra J, de Oliveira Galvao M, et al.
J Paediatr Child Health
. 2022 Jan;
58(6):996-1000.
PMID: 35006634
Aim: This study aimed to evaluate the association of toll-like receptor (TLR) inflammatory cascade with the development of diabetic kidney disease (DKD) in children and adolescents with type 1 diabetes...
2.
Zambrano T, Hirata R, Hirata M, Cerda A, Salazar L
Eur J Pharm Sci
. 2018 Feb;
117:55-61.
PMID: 29427701
Aim: Although statins are considered a cornerstone for the treatment of high cholesterol levels due to their powerful cholesterol-lowering effects, response to drug administration is still one of the main...
3.
de Freitas R, Bortolin R, Lopes M, Tamborlin L, Meneguello L, Silbiger V, et al.
Front Pharmacol
. 2018 Jan;
8:906.
PMID: 29311920
Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful...
4.
Tamashiro E, Felipe C, Genvigir F, Rodrigues A, Campos A, Hirata R, et al.
Drug Metab Pers Ther
. 2017 Jun;
32(2):89-95.
PMID: 28593920
Background: Polymorphisms in genes encoding for drug-metabolizing enzymes and drug transporters are among multiple factors that modulate the pharmacokinetic variability of tacrolimus (TAC) and sirolimus (SRL). This study aimed to...
5.
Ferreira E, Bortolin R, Freire-Neto F, Souza K, Bezerra J, Ururahy M, et al.
Nutr Res
. 2017 May;
40:48-56.
PMID: 28473060
Type 1 diabetes mellitus (T1DM) and estrogen deficiency are associated with several alterations in bone turnover. Zinc (Zn) is required for growth, development, and overall health. Zinc has been used...
6.
Genvigir F, Nishikawa A, Felipe C, Tedesco-Silva Jr H, Oliveira N, Salazar A, et al.
Pharmacotherapy
. 2017 Mar;
37(5):535-545.
PMID: 28316087
Study Objective: To investigate the influence of single nucleotide polymorphisms (SNPs) in genes encoding metabolizing enzymes (CYP2C8, CYP2J2, and UGT2B7) and transporters (ABCC2 and ABCG2) on dose and dose-adjusted trough...
7.
Rodrigues A, Neri E, Verissimo-Filho S, Reboucas N, Hirata R, Yu A
Eur J Pharm Sci
. 2016 Aug;
93:431-6.
PMID: 27575876
Aim: Atorvastatin, a HMG-CoA reductase inhibitor, used in the treatment of hypercholesterolemia, has been previously shown to regulate ABCB1 expression in vivo and in vitro. We hypothesized that the statin...
8.
Genvigir F, Salgado P, Felipe C, Luo E, Alves C, Cerda A, et al.
Pharmacogenet Genomics
. 2016 Jul;
26(10):462-72.
PMID: 27434656
Background: Polymorphisms in genes encoding transport proteins and metabolizing enzymes involved in tacrolimus (TAC) disposition may be important sources of individual variability during treatment. Objective: The aim of this study...
9.
Zambrano T, Hirata R, Hirata M, Cerda A, Salazar L
Cardiovasc Drugs Ther
. 2015 Nov;
29(6):509-518.
PMID: 26602562
Purpose: Statins are widely prescribed drugs to manage hypercholesterolemia. Despite they are considered effective lipid-lowering agents, significant inter-individual variability has been reported in relation to drug response. Among the reasons...
10.
Carvalho V, Andrade P, Rodrigues M, Hirata M, Hirata R, Pannuti C, et al.
J Clin Periodontol
. 2015 Mar;
42(5):440-7.
PMID: 25808980
Aim: A randomized controlled clinical trial was designed to evaluate the efficacy of the photodynamic therapy (PDT) in the treatment of residual pockets of chronic periodontitis patients. Material And Methods:...