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Rosaria Villano

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Articles 12
Citations 32
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Recent Articles
1.
Jorbenadze S, Sprega G, Chelidze A, Sechi B, Dallocchio R, Chankvetadze B, et al.
J Pharm Biomed Anal . 2024 Dec; 255():116643. PMID: 39700865
N-(3-hydroxyacyl)glycines are compounds of remarkable interest due to their biogenic origin and bioactivity and as precursors of the corresponding 3-acyloxy derivatives which represent an important class of bioactive products of...
2.
Villano R, Di Marzo V
Front Chem . 2024 Oct; 12:1436008. PMID: 39449691
A simple and sustainable propylphosphonic anhydride (T3P)-assisted methodology for the synthesis of -acyl tryptamines, an interesting class of gut microbiota-derived endocannabinoid-like lipid mediators, was proposed. This protocol is characterized by...
3.
Villano R, Di Marzo V
Molecules . 2024 Aug; 29(15). PMID: 39125106
The synthesis of some -(3-acyloxyacyl)glycines, an interesting class of bioactive gut microbiota metabolites, is described. This procedure involves seven reaction steps using the commercially available Meldrum's acid to obtain highly...
4.
Roussel C, Sola M, Lessard-Lord J, Nallabelli N, Genereux P, Cavestri C, et al.
Gut Microbes . 2024 May; 16(1):2335879. PMID: 38695302
Dietary omega-3 polyunsaturated fatty acids (-3 PUFAs) and the gut microbiome affect each other. We investigated the impact of supplementation with oil (BO), rich in stearidonic acid (SDA), on the...
5.
Forte N, Roussel C, Marfella B, Lauritano A, Villano R, De Leonibus E, et al.
Commun Biol . 2023 Sep; 6(1):959. PMID: 37735539
N-oleoylglycine (OlGly), a lipid derived from the basic component of olive oil, oleic acid, and N-oleoylalanine (OlAla) are endocannabinoid-like mediators. We report that OlGly and OlAla, by activating the peroxisome...
6.
Dubuc I, Prunier J, Lacasse E, Gravel A, Puhm F, Allaeys I, et al.
Front Immunol . 2022 Jul; 13:893792. PMID: 35812400
Coronavirus disease 19 (COVID-19) is the clinical manifestation of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection. A hallmark of COVID-19 is a lung inflammation characterized by an abundant leukocyte...
7.
Villano R, Tinto F, Di Marzo V
Front Chem . 2022 Mar; 10:858854. PMID: 35300384
Commendamide, or N-(3-hydroxypalmitoyl)-glycine , is a gut microbiota-derived bioactive metabolite, structurally similar to long-chain N-acyl-amino acids which belong to the complex lipid signaling system known as endocannabinoidome and play important...
8.
Tinto F, Villano R, Kostrzewa M, Ligresti A, Straker H, Manzo E
J Nat Prod . 2020 Jul; 83(7):2060-2065. PMID: 32649196
A simple synthesis of the major oxidized metabolites in mammalian tissues of (-)-Δ-tetrahydrocannabivarin (THCV) () has been accomplished by kinetic studies of allylic oxidation using SeO on botanically derived THCV...
9.
Peluso P, Mamane V, Dallocchio R, Dessi A, Villano R, Sanna D, et al.
J Sep Sci . 2017 Dec; 41(6):1247-1256. PMID: 29239526
In the last few years, halogen bonds have been exploited in a variety of research areas both in the solid state and in solution. Nevertheless, several factors make formation and...
10.
Ligresti A, Villano R, Allara M, Ujvary I, Di Marzo V
Pharmacol Res . 2012 Apr; 66(2):163-9. PMID: 22525682
To investigate the possible interactions between kavalactone-based molecules and proteins of the endocannabinoid system and provide novel and synthetically accessible structural scaffolds for the design of cannabinoid receptor ligands sharing...