Ronney A De Abreu
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Explore the profile of Ronney A De Abreu including associated specialties, affiliations and a list of published articles.
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10
Citations
185
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Recent Articles
1.
Brouwer C, Vermunt-de Koning D, Trueworthy R, Ter Riet P, Duley J, Trijbels F, et al.
Pediatr Blood Cancer
. 2005 Dec;
46(4):434-8.
PMID: 16333815
Background: Inosine 5'-monophosphate dehydrogenase (IMPDH; EC1.1.1.205) catalyzes the rate-limiting step in guanine nucleotide biosynthesis, and may play an important role in treatment of patients with antipurines. Methods: We used an...
2.
Brouwer C, Vogels-Mentink T, Keizer-Garritsen J, Trijbels F, Bokkerink J, Hoogerbrugge P, et al.
Clin Chim Acta
. 2005 Jul;
361(1-2):95-103.
PMID: 15990089
Thiopurines are used for treatment of several diseases. Cytotoxicity is caused by the derived compounds 6-thioguanine nucleotides (TGNs) and methyl-6-thioinosine monophosphate (methylthio-IMP). The 6-thiopurine mononucleotides 6-thio-IMP (thio-IMP), 6-thio-GMP (thio-GMP) and...
3.
Brouwer C, De Abreu R, Keizer-Garritsen J, Lambooy L, Ament K, Ter Riet P, et al.
Eur J Cancer
. 2005 Mar;
41(4):613-23.
PMID: 15737567
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme, catalysing S-methylation of aromatic and heterocyclic sulphhydryl compounds. TPMT activities and genotypes have been determined in patients with acute lymphoblastic leukaemia (ALL) and...
4.
de Graaf A, van den Heuvel L, Dijkman H, De Abreu R, Birkenkamp K, de Witte T, et al.
Exp Cell Res
. 2004 Sep;
299(2):533-40.
PMID: 15350550
Bcl-2 family proteins regulate apoptosis at the level of mitochondria. To examine the mechanism of Bcl-2 function, we investigated the effects of the protonophore carbonyl cyanide m-chlorophenyl hydrazone (CCCP) on...
5.
Lambooy L, Gidding C, van den Heuvel L, Hulsbergen-van de Kaa C, Ligtenberg M, Bokkerink J, et al.
Clin Cancer Res
. 2003 Feb;
9(2):812-9.
PMID: 12576454
Purpose: The purpose of this study was to establish a sensitive and semiquantitative method for the detection of minimal residual disease of neuroblastoma, the most common solid tumor in childhood....
6.
Ruitenbeek W, Kobayashi K, Iijima M, Smeitink J, Engelke U, De Abreu R, et al.
Ann Clin Biochem
. 2003 Jan;
40(Pt 1):102-7.
PMID: 12542919
In a patient with microcephaly, feeding problems and restlessness, moderately increased serum and urine citrulline concentrations were observed. Protein and allopurinol loading did not result in additional indications for a...
7.
Keizer-Garritsen J, Brouwer C, Lambooy L, Ter Riet P, Bokkerink J, Trijbels F, et al.
Ann Clin Biochem
. 2003 Jan;
40(Pt 1):86-93.
PMID: 12542916
Background: Monitoring 6-thiopurine S-methyltransferase (TPMT; EC 2.1.1.67) activity is especially important when patients are treated with 6-thiopurine drugs, since severe bone marrow toxicity may be induced if patients have deficient...
8.
De Abreu R, Trueworthy R, van Kuilenburg A, Vogels-Mentink T, Lambooy L, van Gennip A
Ann Clin Biochem
. 2003 Jan;
40(Pt 1):70-4.
PMID: 12542913
Background: Methotrexate (MTX) followed by 6-mercaptopurine (6MP) is one of the best known combinations for the treatment of childhood acute lymphoblastic leukaemia. Tiazofurin (TF) and 6-thioguanine (TG) are also used...
9.
van Kuilenburg A, De Abreu R, van Gennip A
Ann Clin Biochem
. 2003 Jan;
40(Pt 1):41-5.
PMID: 12542909
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU). A deficiency of DPD is increasingly being recognized as the cause of an important pharmacogenetic...
10.
Sumi S, Marinaki A, Arenas M, Fairbanks L, Rees D, Thein S, et al.
Hum Genet
. 2002 Oct;
111(4-5):360-7.
PMID: 12384777
Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency is a common inherited condition characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes. The genetic basis and pathological consequences of ITPase deficiency...