Ronan P Murphy
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Explore the profile of Ronan P Murphy including associated specialties, affiliations and a list of published articles.
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27
Citations
583
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Recent Articles
11.
Wallace R, Twomey L, Custaud M, Moyna N, Cummins P, Mangone M, et al.
Biomed Res Int
. 2016 Mar;
2016:2465763.
PMID: 26942189
Biomarkers encompass a wide range of different measurable indicators, representing a tangible link to physiological changes occurring within the body. Accessibility, sensitivity, and specificity are significant factors in biomarker suitability....
12.
Forde H, Harper E, Davenport C, Rochfort K, Wallace R, Murphy R, et al.
Atherosclerosis
. 2016 Feb;
247:87-96.
PMID: 26878368
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to the tumour necrosis factor (TNF) cytokine superfamily. TRAIL is expressed by numerous cell types including...
13.
McGinn C, MacDonnell B, Shan C, Wallace R, Cummins P, Murphy R
Curr Clin Pharmacol
. 2016 Jan;
11(1):28-42.
PMID: 26725878
Microvesicles (MVs) are submicron intact particles released from the cellular membrane of eukaryotic cells. MVs can be sub-categorised into microparticles (MPs), which are between 100nm- 1micron in size, and exosomes,...
14.
Kotagama K, Babb C, Wolter J, Murphy R, Mangone M
BMC Genomics
. 2015 Dec;
16:1036.
PMID: 26645212
Background: 3'untranslated regions (3'UTRs) are poorly understood portions of eukaryotic mRNAs essential for post-transcriptional gene regulation. Sequence elements in 3'UTRs can be target sites for regulatory molecules such as RNA...
15.
Martin F, McLoughlin A, Rochfort K, Davenport C, Murphy R, Cummins P
PLoS One
. 2014 Sep;
9(9):e108254.
PMID: 25238231
Background And Objectives: Thrombomodulin (TM), an integral membrane glycoprotein expressed on the lumenal surface of vascular endothelial cells, promotes anti-coagulant and anti-inflammatory properties. Release of functional TM from the endothelium...
16.
Rochfort K, Collins L, Murphy R, Cummins P
PLoS One
. 2014 Jul;
9(7):e101815.
PMID: 24992685
Background And Objectives: Blood-brain barrier (BBB) dysfunction is an integral feature of neurological disorders and involves the action of multiple proinflammatory cytokines on the microvascular endothelial cells lining cerebral capillaries....
17.
Guinan A, Rochfort K, Fitzpatrick P, Walsh T, Pierotti A, Phelan S, et al.
Cardiovasc Res
. 2013 May;
99(3):545-54.
PMID: 23708739
Aims: Thimet oligopeptidase (TOP, endopeptidase EC3.4.24.15) is a soluble metallopeptidase known to be expressed within the mammalian vasculature. We examine for the first time the relationship between TOP expression and...
18.
Martin F, Murphy R, Cummins P
Am J Physiol Heart Circ Physiol
. 2013 Apr;
304(12):H1585-97.
PMID: 23604713
Thrombomodulin (TM) is a 557-amino acid protein with a broad cell and tissue distribution consistent with its wide-ranging physiological roles. When expressed on the lumenal surface of vascular endothelial cells...
19.
Macaulay I, Thon J, Tijssen M, Steele B, MacDonald B, Meade G, et al.
Blood
. 2012 Nov;
121(1):188-96.
PMID: 23160460
Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways...
20.
Walsh T, Murphy R, Fitzpatrick P, Rochfort K, Guinan A, Murphy A, et al.
J Cell Physiol
. 2011 Feb;
226(11):3053-63.
PMID: 21302304
Blood-brain barrier (BBB) regulation involves the coordinated interaction of intercellular adherens and tight junctions in response to stimuli. One such stimulus, shear stress, has been shown to upregulate brain microvascular...