Ronald L Alkana
Overview
Explore the profile of Ronald L Alkana including associated specialties, affiliations and a list of published articles.
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26
Citations
622
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Recent Articles
1.
Asatryan L, Khoja S, Rodgers K, Alkana R, Tsukamoto H, Davies D
J Neuroimmunol
. 2015 Jul;
285:169-79.
PMID: 26198936
The present investigation tested the role of ATP-activated P2X7 receptors (P2X7Rs) in alcohol-induced brain damage using a model that combines intragastric (iG) ethanol feeding and high fat diet in C57BL/6J...
2.
Yardley M, Huynh N, Rodgers K, Alkana R, Davies D
Alcohol
. 2015 Jun;
49(6):553-9.
PMID: 26095588
Individuals suffering from an alcohol-use disorder (AUD) constitute a major health concern. Preclinical studies in our laboratory show that acute and chronic intraperitoneal (i.p.) administration of ivermectin (IVM) reduces alcohol...
3.
Naito A, Muchhala K, Asatryan L, Trudell J, Homanics G, Perkins D, et al.
Mol Pharmacol
. 2014 Sep;
86(6):635-46.
PMID: 25245406
A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol...
4.
Yardley M, Neely M, Huynh N, Asatryan L, Louie S, Alkana R, et al.
Neuroreport
. 2014 Jul;
25(13):1018-23.
PMID: 25004078
Ivermectin (IVM), an FDA approved anthelmintic agent, can significantly reduce ethanol intake in mice following acute administration. The current study evaluates the sustainability and safety of multiday IVM administration in...
5.
Wyatt L, Finn D, Khoja S, Yardley M, Asatryan L, Alkana R, et al.
Neurochem Res
. 2014 Mar;
39(6):1127-39.
PMID: 24671605
P2X receptors (P2XRs) are a family of cation-permeable ligand-gated ion channels activated by synaptically released extracellular adenosine 5'-triphosphate. The P2X4 subtype is abundantly expressed in the central nervous system and...
6.
Asatryan L, Yardley M, Khoja S, Trudell J, Hyunh N, Louie S, et al.
Int J Neuropsychopharmacol
. 2014 Jan;
17(6):907-16.
PMID: 24451653
Our laboratory is investigating ivermectin (IVM) and other members of the avermectin family as new pharmaco-therapeutics to prevent and/or treat alcohol use disorders (AUDs). Earlier work found that IVM significantly...
7.
Olsen R, Li G, Wallner M, Trudell J, Bertaccini E, Lindahl E, et al.
Alcohol Clin Exp Res
. 2013 Oct;
38(3):595-603.
PMID: 24164436
The molecular mechanism(s) of action of anesthetic, and especially, intoxicating doses of alcohol (ethanol [EtOH]) have been of interest even before the advent of the Research Society on Alcoholism. Recent...
8.
Wyatt L, Godar S, Khoja S, Jakowec M, Alkana R, Bortolato M, et al.
Neuropsychopharmacology
. 2013 Apr;
38(10):1993-2002.
PMID: 23604007
Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosine 5'-triphosphate (ATP). Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brain,...
9.
Bortolato M, Yardley M, Khoja S, Godar S, Asatryan L, Finn D, et al.
Int J Neuropsychopharmacol
. 2012 Nov;
16(5):1059-70.
PMID: 23174033
Purinergic ionotropic P2X receptors are a family of cation-permeable channels that bind extracellular adenosine 5'-triphosphate. In particular, convergent lines of evidence have recently highlighted P2X(4) receptors as a potentially critical...
10.
Yardley M, Wyatt L, Khoja S, Asatryan L, Ramaker M, Finn D, et al.
Neuropharmacology
. 2012 Apr;
63(2):190-201.
PMID: 22465817
The high rate of therapeutic failure in the management of alcohol use disorders (AUDs) underscores the urgent need for novel and effective strategies that can deter ethanol consumption. Recent findings...