Ronald Kluger
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Explore the profile of Ronald Kluger including associated specialties, affiliations and a list of published articles.
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71
Citations
294
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Recent Articles
1.
Lee C, Chung H, Kluger R
Chembiochem
. 2024 Jun;
25(16):e202400206.
PMID: 38837740
A one-to-one conjugate of cross-linked human hemoglobin and human serum albumin results from a strain-promoted alkyne-azide cycloaddition (SPAAC) of the modified proteins. Additions of a strained alkyne-substituted maleimide to the...
2.
Kim Y, Huang L, Wu N, Kluger R
Bioorg Chem
. 2024 May;
149:107464.
PMID: 38810483
While cross-linked hemoglobin tetramers are functional acellular oxygen carriers, their ability to scavenge endogenous nitric oxide (NO) by endothelial pore penetration results in adverse cardiovascular effects. Animal studies established that...
3.
Zambri M, Kluger R
J Am Chem Soc
. 2024 Jan;
146(2):1403-1409.
PMID: 38176895
Aromatic π-interactions have been recognized as enhancing enzymatic catalytic processes, providing an efficient route to overcome entropic barriers. A nonenzymic analogue, a complex of protonated pyridine and a phenyl substituent...
4.
Kim Y, Kluger R
Org Biomol Chem
. 2022 Oct;
20(41):8083-8091.
PMID: 36205177
Chemical cross-linking of human adult hemoglobin (Hb) prevents dissociation of the tetrameric (αβ) protein into its constituent non-functional αβ dimers when present outside red cells, providing the possibility of being...
5.
Wu N, Kluger R
Bioorg Chem
. 2022 Jan;
120:105579.
PMID: 35030479
Rates of fluoride elimination and iodination of the Breslow intermediate (BI) derived from 2-(1-hydroxy-2,2,2-trifluoroethyl)-thiamin provide a quantitative assessment of competing reactions at C2α of the BI. The competition probes the...
6.
Zhou S, Nguyen B, Richard J, Kluger R, Gao J
J Am Chem Soc
. 2021 Apr;
143(15):6018.
PMID: 33822616
No abstract available.
7.
Zhou S, Nguyen B, Richard J, Kluger R, Gao J
J Am Chem Soc
. 2020 Dec;
143(1):137-141.
PMID: 33375792
In aqueous solution, biological decarboxylation reactions proceed irreversibly to completion, whereas the reverse carboxylation processes are typically powered by the hydrolysis of ATP. The exchange of the carboxylate of ring-substituted...
8.
Bielecki M, Howe G, Kluger R
Biochemistry
. 2019 Aug;
58(34):3566-3571.
PMID: 31385510
Decarboxylation reactions from comparable thiamin diphosphate- and thiamin-derived adducts of -(halomethyl)benzoylformic acids in enzymic and non-enzymic reactions, respectively, reveal critical distinctions in otherwise similar Breslow intermediates. The ratio of protonation...
9.
Wang A, Singh S, Yu B, Bloch D, Zapol W, Kluger R
Transfusion
. 2018 Nov;
59(1):359-370.
PMID: 30444016
Background: Hemoglobin-based oxygen carriers (HBOCs) are potential alternatives to red blood cells in transfusions. Clinical trials using early versions of HBOCs noted adverse effects that appeared to result from removal...
10.
Bielecki M, Howe G, Kluger R
Biochemistry
. 2018 Jun;
57(26):3867-3872.
PMID: 29856601
The enzymic decarboxylation of 2-ketoacids proceeds via their C2-thiazolium adducts of thiamin diphosphate (ThDP). Loss of CO from these adducts leads to reactive species that are known as Breslow intermediates....