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Ronald E Van Kesteren

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Recent Articles
1.
Attwell C, Maldonado-Lasuncion I, Eggers R, Bijleveld B, Ellenbroek W, Siersema N, et al.
Mol Neurodegener . 2025 Feb; 20(1):18. PMID: 39923113
Background: Axon regeneration after injury to the central nervous system (CNS) is limited by an inhibitory environment but also because injured neurons fail to initiate expression of regeneration associated genes...
2.
van Nifterick A, de Haan W, Stam C, Hillebrand A, Scheltens P, Van Kesteren R, et al.
Brain Commun . 2024 Dec; 6(6):fcae423. PMID: 39713236
Understanding the nature and onset of neurophysiological changes, and the selective vulnerability of central hub regions in the functional network, may aid in managing the growing impact of Alzheimer's disease...
3.
Lucassen P, Korosi A, de Rooij S, Smit A, Van Dam A, Daskalakis N, et al.
Biol Psychiatry . 2024 Nov; 97(4):372-381. PMID: 39577793
Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder to which genetic mutations and risk factors contribute. Evidence is increasing that environmental and lifestyle-related factors, such as exercise, nutrition, education,...
4.
Abdollahi Nejat M, Stiedl O, Smit A, Van Kesteren R
Front Behav Neurosci . 2024 Sep; 18:1457894. PMID: 39296476
Locomotor activity can serve as a readout to identify discomfort and pain. Therefore, monitoring locomotor activity following interventions that induce potential discomfort may serve as a reliable method for evaluating...
5.
de Veij Mestdagh C, Smit A, Henning R, Van Kesteren R
Cells . 2024 Jan; 13(1). PMID: 38201215
Alzheimer's disease (AD) is the most common cause of dementia worldwide and yet remains without effective therapy. Amongst the many proposed causes of AD, the mitochondrial cascade hypothesis is gaining...
6.
van Heusden F, van Nifterick A, Souza B, Franca A, Nauta I, Stam C, et al.
Alzheimers Res Ther . 2023 Aug; 15(1):142. PMID: 37608393
Background: Studies in animal models of Alzheimer's disease (AD) have provided valuable insights into the molecular and cellular processes underlying neuronal network dysfunction. Whether and how AD-related neurophysiological alterations translate...
7.
Hijazi S, Smit A, Van Kesteren R
Mol Psychiatry . 2023 Jul; 28(12):4954-4967. PMID: 37419975
Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique morphological and functional properties that allow them to precisely control local circuitry, brain networks and memory processing. Since the discovery in...
8.
Bouland G, Marinus K, Van Kesteren R, Smit A, Mahfouz A, Reinders M
medRxiv . 2023 Jun; PMID: 37292975
Understanding how genetic risk variants contribute to Alzheimer's Disease etiology remains a challenge. Single-cell RNA sequencing (scRNAseq) allows for the investigation of cell type specific effects of genomic risk loci...
9.
van Nifterick A, Mulder D, Duineveld D, Diachenko M, Scheltens P, Stam C, et al.
Sci Rep . 2023 May; 13(1):7419. PMID: 37150756
An early disruption of neuronal excitation-inhibition (E-I) balance in preclinical animal models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure directly and non-invasively in humans....
10.
de Veij Mestdagh C, Koopmans F, Breiter J, Timmerman J, Vogelaar P, Krenning G, et al.
Alzheimers Res Ther . 2022 Dec; 14(1):183. PMID: 36482297
Background: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide and remains without effective cure. Increasing evidence is supporting the mitochondrial cascade hypothesis, proposing that loss of mitochondrial fitness...