Ronald A Siegel
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Explore the profile of Ronald A Siegel including associated specialties, affiliations and a list of published articles.
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68
Citations
416
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Recent Articles
1.
Jain K, Duggal I, Hou H, Siegel R
Eur J Pharm Biopharm
. 2025 Mar;
:114688.
PMID: 40089075
The objective of this study was to develop a scheme to predict intestinal and plasma concentration-time profiles of the weakly basic BCS-II drug, Dipyridamole (DPD), using an Artificial Gut Simulator...
2.
Wang Z, Song S, Zhang H, Liu X, Siegel R, Sun C, et al.
Int J Pharm
. 2024 Dec;
670:125081.
PMID: 39710308
Interest in oral delivery of biological drug products, commonly prepared through lyophilization, is surging. Typically, low solid content solutions are employed for lyophilization to enhance mass transfer and minimize drying...
3.
Song S, Xu J, Chen Z, Sun C, Munson E, Siegel R
J Pharm Sci
. 2024 May;
114(1):119-126.
PMID: 38796157
Miscibility is critical in the prediction of stability against crystallization of amorphous solid dispersions (ASDs) in the solid state. However, currently available approaches for its determination are limited by both...
4.
Song S, Yao X, Wang C, Sun C, Siegel R
J Pharm Sci
. 2024 Apr;
114(1):98-104.
PMID: 38685452
A thorough understanding of effects of polymers on crystallization of amorphous drugs is essential for rational design of robust amorphous solid dispersion (ASD), since crystallization of the amorphous drug negates...
5.
Jain K, Hou H, Siegel R
Mol Pharm
. 2024 Mar;
21(4):1884-1899.
PMID: 38512389
Upon dissolution, amorphous solid dispersions (ASDs) of poorly water-soluble compounds can generate supersaturated solutions consisting of bound and free drug species that are in dynamic equilibrium with each other. Only...
6.
Song S, Cui S, Sun C, Lodge T, Siegel R
J Pharm Sci
. 2024 Feb;
114(1):82-88.
PMID: 38369019
Low concentration polymer additives can significantly alter crystal growth kinetics of molecular liquids and glasses. However, the effect of polymer concentration on nucleation kinetics remains poorly understood. Based on an...
7.
Siegel R
AAPS J
. 2023 Dec;
26(1):8.
PMID: 38114869
Recent publications by Benet and coworkers, Korzekwa and Nagar, and Rowland et al. signal disagreement regarding the use of Kirchhoff's laws in combining pharmacokinetic parameters, especially clearances and rate constants....
8.
Sahoo A, Siegel R
Pharm Res
. 2023 Aug;
40(9):2229-2237.
PMID: 37552386
Objectives: Amorphous solid dispersions (ASDs), wherein a drug is molecularly dispersed in a polymer, can improve physical stability and oral bioavailability of poorly soluble drugs. Risk of drug crystallization is...
9.
Wang Z, Wang L, Ebbini M, Curran G, Min P, Siegel R, et al.
J Pharmacol Exp Ther
. 2023 May;
386(1):102-110.
PMID: 37221092
Plasma pharmacokinetic (PK) data are required as an input function for graphical analysis of single positron emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/CT (PET/CT) data to evaluate tissue...
10.
Jain K, Siegel R
J Control Release
. 2023 Mar;
357:422-431.
PMID: 36940773
"Pulsed drug release" for dosing drugs such as vaccines, hormones etc. that require multiple, predetermined release events can be obtained by using capsules that exploit the principle of osmosis to...