Romy Bottcher
Overview
Explore the profile of Romy Bottcher including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
266
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0
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Recent Articles
1.
Bottcher R, Schmidts I, Nitschko V, duric P, Forstemann K
RNA Biol
. 2021 Dec;
19(1):68-77.
PMID: 34965182
DNA double-strand breaks are among the most toxic lesions that can occur in a genome and their faithful repair is thus of great importance. Recent findings have uncovered local transcription...
2.
Tants J, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, et al.
Nucleic Acids Res
. 2017 Oct;
45(21):12536-12550.
PMID: 29040648
RNA interference defends against RNA viruses and retro-elements within an organism's genome. It is triggered by duplex siRNAs, of which one strand is selected to confer sequence-specificity to the RNA...
3.
Merk K, Breinig M, Bottcher R, Krebs S, Blum H, Boutros M, et al.
PLoS Genet
. 2017 Jun;
13(6):e1006861.
PMID: 28628606
DNA double-strand breaks trigger the production of locus-derived siRNAs in fruit flies, human cells and plants. At least in flies, their biogenesis depends on active transcription running towards the break....
4.
Schmidts I, Bottcher R, Mirkovic-Hosle M, Forstemann K
Nucleic Acids Res
. 2016 Jun;
44(17):8261-71.
PMID: 27353331
Small interfering RNAs (siRNAs) defend the organism against harmful transcripts from exogenous (e.g. viral) or endogenous (e.g. transposons) sources. Recent publications describe the production of siRNAs induced by DNA double-strand...
5.
Kunzelmann S, Bottcher R, Schmidts I, Forstemann K
G3 (Bethesda)
. 2016 May;
6(6):1777-85.
PMID: 27172193
Custom genome editing has become an essential element of molecular biology. In particular, the generation of fusion constructs with epitope tags or fluorescent proteins at the genomic locus facilitates the...
6.
Bottcher R, Hollmann M, Merk K, Nitschko V, Obermaier C, Philippou-Massier J, et al.
Nucleic Acids Res
. 2014 Apr;
42(11):e89.
PMID: 24748663
The ability to edit the genome is essential for many state-of-the-art experimental paradigms. Since DNA breaks stimulate repair, they can be exploited to target site-specific integration. The clustered, regularly interspaced,...
7.
Michalik K, Bottcher R, Forstemann K
Nucleic Acids Res
. 2012 Aug;
40(19):9596-603.
PMID: 22848104
Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA...
8.
Hartig J, Esslinger S, Bottcher R, Saito K, Forstemann K
EMBO J
. 2009 Aug;
28(19):2932-44.
PMID: 19644447
Colonization of genomes by a new selfish genetic element is detrimental to the host species and must lead to an efficient, repressive response. In vertebrates as well as in Drosophila,...