Ralf Stehle
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Explore the profile of Ralf Stehle including associated specialties, affiliations and a list of published articles.
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22
Citations
408
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Recent Articles
1.
Soni K, Jagtap P, Martinez-Lumbreras S, Bonnal S, Geerlof A, Stehle R, et al.
Nat Commun
. 2023 Jul;
14(1):4233.
PMID: 37454201
The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of genes important for apoptosis and cell proliferation and have been implicated...
2.
Keil P, Wulf A, Kachariya N, Reuscher S, Huhn K, Silbern I, et al.
Nucleic Acids Res
. 2022 Dec;
51(2):831-851.
PMID: 36583366
RNA-binding proteins (RBPs) control every RNA metabolic process by multiple protein-RNA and protein-protein interactions. Their roles have largely been analyzed by crude mutations, which abrogate multiple functions at once and...
3.
Lopez A, Dahiya V, Delhommel F, Freiburger L, Stehle R, Asami S, et al.
Sci Adv
. 2021 Dec;
7(51):eabl7295.
PMID: 34919431
Hsp90 is a molecular chaperone that interacts with a specific set of client proteins and assists their folding. The underlying molecular mechanisms, involving dynamic transitions between open and closed conformations,...
4.
Jussupow A, Messias A, Stehle R, Geerlof A, Solbak S, Paissoni C, et al.
Sci Adv
. 2020 Oct;
6(42).
PMID: 33055165
Polyubiquitin chains are flexible multidomain proteins, whose conformational dynamics enable them to regulate multiple biological pathways. Their dynamic is determined by the linkage between ubiquitins and by the number of...
5.
Heckmeier P, Agam G, Teese M, Hoyer M, Stehle R, Lamb D, et al.
Biophys J
. 2020 Jun;
119(1):99-114.
PMID: 32553128
A large fraction of soluble and membrane-bound proteins exists as non-covalent dimers, trimers, and higher-order oligomers. The experimental determination of the oligomeric state or stoichiometry of proteins remains a nontrivial...
6.
Kang H, Sanchez-Rico C, Ebersberger S, Sutandy F, Busch A, Welte T, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(13):7140-7149.
PMID: 32188783
The recognition of -regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular features that determine RBP specificity are often poorly understood....
7.
Pabis M, Popowicz G, Stehle R, Fernandez-Ramos D, Asami S, Warner L, et al.
Nucleic Acids Res
. 2018 Nov;
47(2):1011-1029.
PMID: 30418581
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure...
8.
Tants J, Fesser S, Kern T, Stehle R, Geerlof A, Wunderlich C, et al.
Nucleic Acids Res
. 2017 Oct;
45(21):12536-12550.
PMID: 29040648
RNA interference defends against RNA viruses and retro-elements within an organism's genome. It is triggered by duplex siRNAs, of which one strand is selected to confer sequence-specificity to the RNA...
9.
Sonntag M, Jagtap P, Simon B, Appavou M, Geerlof A, Stehle R, et al.
Angew Chem Int Ed Engl
. 2017 Jun;
56(32):9322-9325.
PMID: 28636238
Multi-domain proteins play critical roles in fine-tuning essential processes in cellular signaling and gene regulation. Typically, multiple globular domains that are connected by flexible linkers undergo dynamic rearrangements upon binding...
10.
Schlundt A, Buchner S, Janowski R, Heydenreich T, Heermann R, Lassak J, et al.
Sci Rep
. 2017 Apr;
7(1):1051.
PMID: 28432336
The transmembrane DNA-binding protein CadC of E. coli, a representative of the ToxR-like receptor family, combines input and effector domains for signal sensing and transcriptional activation, respectively, in a single...