Rommel Mallari
Overview
Explore the profile of Rommel Mallari including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
131
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0
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Recent Articles
1.
Dou H, Mallari R, Pipathsouk A, Das A, Lo M
SLAS Discov
. 2020 Oct;
26(2):281-291.
PMID: 33016168
Since the revolutionary discovery of RNA interference (RNAi) more than 20 years ago, synthetic small interfering RNAs (siRNAs) have held great promise as therapeutic agents for treating human diseases by...
2.
Rescourio G, Gonzalez A, Jabri S, Belmontes B, Moody G, Whittington D, et al.
J Med Chem
. 2019 Nov;
62(22):10258-10271.
PMID: 31736296
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of...
3.
Graves J, Kordich J, Huang T, Piasecki J, Bush T, Sullivan T, et al.
Cancer Cell
. 2014 Jul;
26(2):177-89.
PMID: 25043603
Death receptor agonist therapies have exhibited limited clinical benefit to date. Investigations into why Apo2L/TRAIL and AMG 655 preclinical data were not predictive of clinical response revealed that coadministration of...
4.
Wong S, Mallari R, Graham M, Atangan L, Lu S, Zhao X, et al.
Assay Drug Dev Technol
. 2010 May;
8(4):459-70.
PMID: 20482379
Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through G-protein-coupled receptors to produce a range of biological responses. A recently reported LPA receptor GPR23 (LPA4 receptor) has a low...
5.
Zhao X, Jones A, Olson K, Peng K, Wehrman T, Park A, et al.
J Biomol Screen
. 2008 Jul;
13(8):737-47.
PMID: 18660457
G-protein-coupled receptors (GPCRs) represent one of the largest gene families in the human genome and have long been regarded as valuable targets for small-molecule drugs. The authors describe a new...
6.
Hong C, Swearingen E, Mallari R, Gao X, Cao Z, North A, et al.
Assay Drug Dev Technol
. 2004 Apr;
1(1 Pt 2):175-80.
PMID: 15090144
Interleukin 1 receptor activation innervates a cascade of signal transduction events that ultimately lead to the activation of inflammatory and immune response genes. TRAF6 is a Ub ligase (E3) involved...
7.
Mallari R, Swearingen E, Liu W, Ow A, Young S, Huang S
J Biomol Screen
. 2003 Jul;
8(2):198-204.
PMID: 12844441
A generic high-throughput screening assay based on the scintillation proximity assay technology has been developed for protein kinases. In this assay, the biotinylated (33)P-peptide product is captured onto polylysine Ysi...