Romario Regeenes
Overview
Explore the profile of Romario Regeenes including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
51
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Recent Articles
1.
Regeenes R, Rocheleau J
Lab Chip
. 2024 Jan;
24(5):1327-1350.
PMID: 38277011
Pancreatic islets are metabolically active micron-sized tissues responsible for controlling blood glucose through the secretion of insulin and glucagon. A loss of functional islet mass results in type 1 and...
2.
Wang Y, Regeenes R, Memon M, Rocheleau J
Cell Rep Methods
. 2023 Oct;
3(10):100602.
PMID: 37820726
First-phase glucose-stimulated insulin secretion is mechanistically linked to type 2 diabetes, yet the underlying metabolism is difficult to discern due to significant islet-to-islet variability. Here, we miniaturize a fluorescence anisotropy...
3.
Rafiei N, Moghadam M, Au A, Regeenes R, Chidambaram S, Liang T, et al.
Biofabrication
. 2022 Jul;
14(4).
PMID: 35793653
Precision-cut-tissues (PCTs), which preserve many aspects of a tissue's microenvironment, are typically imaged using conventional sample dishes and chambers. These can require large amounts of reagent and, when used for...
4.
Pal V, Wang Y, Regeenes R, Kilkenny D, Rocheleau J
Sci Rep
. 2022 Apr;
12(1):6110.
PMID: 35414066
We previously showed that pancreatic beta-cells plated on laminin matrix express reduced levels of FGFR1, a receptor linked to beta-cell metabolism and differentiation. Due to recent evidence that adult beta-cells...
5.
Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro A, Song Y, et al.
JCI Insight
. 2021 May;
6(10).
PMID: 34027899
GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to...
6.
Kim M, Febbraro D, Farkona S, Gillmore T, Son J, Regeenes R, et al.
Mol Metab
. 2021 Feb;
47:101185.
PMID: 33561544
Objective: Autophagy is a physiological self-eating process that can promote cell survival or activate cell death in eukaryotic cells. In skeletal muscle, it is important for maintaining muscle mass and...
7.
Regeenes R, Silva P, Chang H, Arany E, Shukalyuk A, Audet J, et al.
J Biol Chem
. 2018 Sep;
293(44):17218-17228.
PMID: 30217817
Fibroblast growth factor receptor-1 (FGFR1) activity at the plasma membrane is tightly controlled by the availability of co-receptors and competing receptor isoforms. We have previously shown that FGFR1 activity in...
8.
Silva P, Atto Z, Regeenes R, Tufa U, Chen Y, Chan W, et al.
Lab Chip
. 2016 Jul;
16(15):2921-34.
PMID: 27378588
Tissues are challenging to genetically manipulate due to limited penetration of viral particles resulting in low transduction efficiency. We are particularly interested in expressing genetically-encoded sensors in ex vivo pancreatic...