Roland E Kontermann
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Explore the profile of Roland E Kontermann including associated specialties, affiliations and a list of published articles.
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140
Citations
3495
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Recent Articles
1.
Klein C, Brinkmann U, Reichert J, Kontermann R
Nat Rev Drug Discov
. 2024 Mar;
23(4):301-319.
PMID: 38448606
Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic applications that cannot be achieved using conventional IgG-based antibodies. Consequently, development of these molecules has garnered substantial interest in the...
2.
Nguyen K, Bhatt I, Gupta S, Showkat N, Swanson K, Fischer R, et al.
Brain Res Bull
. 2024 Jan;
207:110885.
PMID: 38246200
Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor...
3.
Abassi L, Bertoglio F, Macak Safranko Z, Schirrmann T, Greweling-Pils M, Seifert O, et al.
Viruses
. 2023 Nov;
15(11).
PMID: 38005829
As of now, the COVID-19 pandemic has spread to over 770 million confirmed cases and caused approximately 7 million deaths. While several vaccines and monoclonal antibodies (mAb) have been developed...
4.
Orti-Casan N, Boerema A, Kopke K, Ebskamp A, Keijser J, Zhang Y, et al.
Sci Rep
. 2023 Jun;
13(1):10622.
PMID: 37391534
Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of...
5.
Pegoretti V, Bauer J, Fischer R, Paro I, Douwenga W, Kontermann R, et al.
J Neuroinflammation
. 2023 May;
20(1):106.
PMID: 37138340
TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell...
6.
Fiedler T, Fairless R, Pichi K, Fischer R, Richter F, Kontermann R, et al.
J Neuroinflammation
. 2023 Apr;
20(1):100.
PMID: 37122019
Background: Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of the immune system. It acts through two receptors resulting in often opposing biological effects, which may explain...
7.
Kuhl L, Schafer A, Kraft S, Aschmoneit N, Kontermann R, Seifert O
MAbs
. 2023 Mar;
15(1):2183540.
PMID: 36864566
Bispecific antibodies are molecules with versatile modes of action and applications for therapy. They are commonly developed as T-cell engagers (TCE), which simultaneously target an antigen expressed by tumor cells...
8.
Liang K, Roels J, Lavaert M, Putteman T, Boehme L, Tilleman L, et al.
Nat Immunol
. 2023 Jan;
24(3):474-486.
PMID: 36703005
The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cells (DCs) is evident but its physiological significance is unknown....
9.
Seifert O, Kontermann R
Molecules
. 2022 May;
27(10).
PMID: 35630749
Many therapeutic proteins are small in size and are rapidly cleared from circulation. Consequently, half-life extension strategies have emerged to improve pharmacokinetic properties, including fusion or binding to long-lasting serum...
10.
Kuhl L, Aschmoneit N, Kontermann R, Seifert O
MAbs
. 2022 Apr;
14(1):2063043.
PMID: 35427197
Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation...