Rohan Samarakoon
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Explore the profile of Rohan Samarakoon including associated specialties, affiliations and a list of published articles.
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46
Citations
1458
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Recent Articles
1.
Mondal V, Higgins P, Samarakoon R
Cancers (Basel)
. 2024 Aug;
16(15).
PMID: 39123485
Although Hippo-YAP/TAZ pathway involvement has been extensively studied in the development of certain cancers, the involvement of this cascade in kidney cancer progression is not well-established and, therefore, will be...
2.
Czekay R, Higgins C, Aydin H, Samarakoon R, Subasi N, Higgins S, et al.
Cells
. 2024 May;
13(10.
PMID: 38786020
A heterogenous population of inflammatory elements, other immune and nonimmune cells and cancer-associated fibroblasts (CAFs) are evident in solid malignancies where they coexist with the growing tumor mass. In highly...
3.
Mazumder S, Higgins P, Samarakoon R
Cancers (Basel)
. 2023 Feb;
15(4).
PMID: 36831657
The clear cell variant of renal cell carcinoma (ccRCC) is the most common renal epithelial malignancy and responsible for most of the deaths from kidney cancer. Patients carrying inactivating mutations...
4.
Mende C, Samarakoon R, Higgins P
Am J Nephrol
. 2023 Jan;
54(1-2):50-61.
PMID: 36682353
Background: Diabetic kidney disease (DKD) is a common disorder with multiple serious clinical implications, including an increased risk of end-stage kidney disease (ESKD), cardiovascular complications, heart failure, onset or worsening...
5.
Overstreet J, Gifford C, Tang J, Higgins P, Samarakoon R
Cell Mol Life Sci
. 2022 Aug;
79(9):474.
PMID: 35941392
p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the initiation and progression...
6.
Valentijn F, Knoppert S, Marquez-Exposito L, Rodrigues-Diez R, Pissas G, Tang J, et al.
Kidney Int
. 2022 Aug;
102(6):1305-1319.
PMID: 35921911
Chronic allograft dysfunction with progressive fibrosis of unknown cause remains a major issue after kidney transplantation, characterized by ischemia-reperfusion injury (IRI). One hypothesis to account for this is that spontaneous...
7.
Czekay R, Cheon D, Samarakoon R, Kutz S, Higgins P
Cancers (Basel)
. 2022 Mar;
14(5).
PMID: 35267539
Cancer-associated fibroblasts (CAFs) are a heterogenous population of stromal cells found in solid malignancies that coexist with the growing tumor mass and other immune/nonimmune cellular elements. In certain neoplasms (e.g.,...
8.
Zhang W, Gao C, Tsilosani A, Samarakoon R, Plews R, Higgins P
Am J Physiol Renal Physiol
. 2022 Feb;
322(4):F379-F391.
PMID: 35100814
Mammalian kidneys consist of more than 30 different types of cells. A challenging task is to identify and characterize the stem/progenitor subpopulations that establish the lineage relationships among these cellular...
9.
Heiserman J, Nallanthighal S, Gifford C, Graham K, Samarakoon R, Gao C, et al.
Cancers (Basel)
. 2021 Oct;
13(19).
PMID: 34638339
Collagen type XI alpha 1 (COL11A1) is a novel biomarker associated with cisplatin resistance in ovarian cancer. We have previously reported that COL11A1 activates Src-Akt signaling through the collagen receptors...
10.
Ryan K, Ashkavand Z, Sarasija S, Laboy J, Samarakoon R, Norman K
Aging Cell
. 2021 Sep;
20(10):e13472.
PMID: 34499406
Metabolic dysfunction and protein aggregation are common characteristics that occur in age-related neurodegenerative disease. However, the mechanisms underlying these abnormalities remain poorly understood. We have found that mutations in the...