Roger J Melton
Overview
Explore the profile of Roger J Melton including associated specialties, affiliations and a list of published articles.
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8
Citations
98
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0
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Recent Articles
1.
Touchette E, Bates M, Johnson M, OBrien T, Melton R, Long K, et al.
Comp Med
. 2023 Feb;
72(6):355-363.
PMID: 36744513
Humanized liver chimeric mice (PXB-mice) are generated by the transplantation of human hepatocytes into mice that have severe combined immunodeficiency and express an albumin-promoted urokinase-type plasminogen activator (cDNA-uPA/SCID) transgene. Human...
2.
Liston T, Hinz S, Muller C, Holstein D, Wendling J, Melton R, et al.
Purinergic Signal
. 2020 Oct;
16(4):543-559.
PMID: 33129204
Rapid phosphoester hydrolysis of endogenous purine and pyrimidine nucleotides has challenged the characterization of the role of P2 receptors in physiology and pathology. Nucleotide phosphoester stabilization has been pursued on...
3.
Weiss G, Chao J, Neidhart J, Ramanathan R, Bassett D, Neidhart J, et al.
Invest New Drugs
. 2013 Feb;
31(4):986-1000.
PMID: 23397498
Patients with advanced solid malignancies were enrolled to an open-label, single-arm, dose-escalation study, in which CRLX101 was administered intravenously over 60 min among two dosing schedules, initially weekly at 6,...
4.
Hutzler J, Linder C, Melton R, Vincent J, Daniels J
Drug Metab Dispos
. 2010 Apr;
38(7):1113-21.
PMID: 20375180
The metabolism of the 5-lipoxygenase inhibitor, 4-(3-(4-(2-methyl-1H-imidazol-1-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide (CJ-13,610), was investigated in liver microsomes from human and preclinical species in an effort to compare metabolite profiles and evaluate the in vitro-in...
5.
Lickteig A, Riley R, Melton R, Reitz B, Fischer H, Stevens J
Drug Metab Dispos
. 2009 Jul;
37(10):1987-90.
PMID: 19635782
Mammalian flavin-containing monooxygenase (FMO) enzymes catalyze oxidation at nucleophilic, heteroatom centers and are important for drug, xenobiotic, and endogenous substrate metabolism. In human liver, human FMO3 (hFMO3) is the most...
6.
Hutzler J, Melton R, Rumsey J, Thompson D, Rock D, Wienkers L
Chem Res Toxicol
. 2008 Apr;
21(5):1125-33.
PMID: 18407675
PH-302 ( 1) demonstrates potent inhibitory activity against the inducible form of nitric oxide synthase (iNOS). The primary metabolite of PH-302 is a catechol ( 2) resulting from oxidative demethylenation...
7.
Hutzler J, Melton R, Rumsey J, Schnute M, Locuson C, Wienkers L
Chem Res Toxicol
. 2006 Dec;
19(12):1650-9.
PMID: 17173379
PH-302 inhibits the inducible form of nitric oxide synthase (iNOS) by coordinating with the heme of the monomeric form and preventing formation of the active dimer. Inherent with the mechanism...
8.
Stevens J, Melton R, Zaya M, Engel L
Mol Pharmacol
. 2003 Jan;
63(2):271-5.
PMID: 12527797
A full-length dog (beagle) flavin-containing monooxygenase 1 (FMO1) cDNA (dFMO1) was obtained from liver by reverse transcription-polymerase chain reaction. The amino acid sequence of dFMO1 was 89% homologous to human...