Roger C Whitehead
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Explore the profile of Roger C Whitehead including associated specialties, affiliations and a list of published articles.
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20
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244
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Recent Articles
1.
Eadsforth M, Kong L, Whitehead G, Vitorica-Yrezabal I, OKeefe R, Bryce R, et al.
Acta Crystallogr E Crystallogr Commun
. 2024 Aug;
80(Pt 8):857-862.
PMID: 39108782
The X-ray crystal structure data of 12-α-fluoro-3β-hy-droxy-olean-28,13β-olide methanol hemisolvate, 2CHFO·CHOH, (), and 12-α-fluoro-3β-hy-droxy-taraxer-28,14β-olide methanol hemisolvate, 2CHFO·CHOH, (), are described. The fluoro-lactonization of oleanolic acid using Selectfluor yielded a mixture of...
2.
Schafer A, Steenhuis M, Jim K, Neef J, OKeefe S, Whitehead R, et al.
ACS Infect Dis
. 2023 Jan;
9(2):253-269.
PMID: 36637435
Eeyarestatin 24 (ES24) is a promising new antibiotic with broad-spectrum activity. It shares structural similarity with nitrofurantoin (NFT), yet appears to have a distinct and novel mechanism: ES24 was found...
3.
Harawa V, Thorpe T, Marshall J, Sangster J, Gilio A, Pirvu L, et al.
J Am Chem Soc
. 2022 Nov;
144(46):21088-21095.
PMID: 36350999
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due...
4.
Steenhuis M, Koningstein G, Oswald J, Pick T, OKeefe S, Koch H, et al.
Mol Microbiol
. 2020 Aug;
115(1):28-40.
PMID: 32798330
Eeyarestatin 1 (ES1) is an inhibitor of endoplasmic reticulum (ER) associated protein degradation, Sec61-dependent Ca homeostasis and protein translocation into the ER. Recently, evidence was presented showing that a smaller...
5.
Megarity C, Abdel-Aal Bettley H, Caraher M, Scott K, Whitehead R, Jowitt T, et al.
Chembiochem
. 2019 Jun;
20(22):2841-2849.
PMID: 31165578
NAD(P)H quinone oxidoreductase-1 (NQO1) is a homodimeric protein that acts as a detoxifying enzyme or as a chaperone protein. Dicourmarol interacts with NQO1 at the NAD(P)H binding site and can...
6.
Gamayun I, OKeefe S, Pick T, Klein M, Nguyen D, McKibbin C, et al.
Cell Chem Biol
. 2019 Feb;
26(4):571-583.e6.
PMID: 30799222
Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca homeostasis...
7.
Baldwin J, Claridge T, Culshaw A, Heupel F, Lee V, Spring D, et al.
Angew Chem Int Ed Engl
. 2018 May;
37(19):2661-2663.
PMID: 29711622
The biomimetic synthesis of a pentacyclic alkaloid (keramaphidin B, 1), an intermediate in the biogenetic pathway to the manzamine alkaloids, has been achieved. Compound 1 was formed by an intramolecular...
8.
Skvortsov T, Hoering P, Arkhipova K, Whitehead R, Boyd D, Allen C
Genome Announc
. 2018 Jan;
6(1).
PMID: 29301889
Here, we present draft genome sequences of strains UV4 and UV4/95, which demonstrate an ability to conduct a wide range of industrially important biotransformations of arenes, alkenes, and phenols.
9.
Edwards A, Geist A, Mullich U, Sharrad C, Pritchard R, Whitehead R, et al.
Chem Commun (Camb)
. 2017 Jul;
53(58):8160-8163.
PMID: 28677706
A broad range of 1,10-phenanthroline substrates was efficiently C-H functionalised, providing rapid, gram-scale access to substituted heteroaromatic cores of broad utility. Furthermore, this C-H functionalisation pathway was extended to the...
10.
Edwards A, Mocilac P, Geist A, Harwood L, Sharrad C, Burton N, et al.
Chem Commun (Camb)
. 2017 Apr;
53(36):5001-5004.
PMID: 28426063
The first hydrophilic, 1,10-phenanthroline derived ligands consisting of only C, H, O and N atoms for the selective extraction of Am(iii) from spent nuclear fuel are reported herein. One of...