Roelof A Wester
Overview
Explore the profile of Roelof A Wester including associated specialties, affiliations and a list of published articles.
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5
Citations
87
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0
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Recent Articles
1.
Wester R, Neikes H, Lindeboom R, Vermeulen M
Nat Protoc
. 2024 Jul;
19(12):3590-3612.
PMID: 39080437
Transcription factors (TFs) bind specific DNA sequences to regulate transcription. Apart from DNA sequences, local factors such as DNA accessibility and chromatin structure determine the affinity of a TF for...
2.
Neikes H, Kliza K, Grawe C, Wester R, Jansen P, Lamers L, et al.
Nat Biotechnol
. 2023 Mar;
41(12):1801-1809.
PMID: 36973556
Transcription factor binding across the genome is regulated by DNA sequence and chromatin features. However, it is not yet possible to quantify the impact of chromatin context on transcription factor...
3.
Wester R, van Voorthuijsen L, Neikes H, Dijkstra J, Lamers L, Frolich S, et al.
iScience
. 2021 Dec;
24(12):103444.
PMID: 34877501
Retinoic acid (RA) signaling is an important and conserved pathway that regulates cellular proliferation and differentiation. Furthermore, perturbed RA signaling is implicated in cancer initiation and progression. However, the mechanisms...
4.
Esk C, Lindenhofer D, Haendeler S, Wester R, Pflug F, Schroeder B, et al.
Science
. 2020 Oct;
370(6519):935-941.
PMID: 33122427
Loss-of-function (LOF) screens provide a powerful approach to identify regulators in biological processes. Pioneered in laboratory animals, LOF screens of human genes are currently restricted to two-dimensional cell cultures, which...
5.
van Mierlo G, Wester R, Marks H
Stem Cell Res
. 2018 Oct;
33:135-145.
PMID: 30352361
The ground state of pluripotency is defined as a minimal unrestricted epigenetic state as present in the Inner Cell Mass. Mouse embryonic stem cells (ESCs) grown in a defined serum-free...