Rodney P DeKoter
Overview
Explore the profile of Rodney P DeKoter including associated specialties, affiliations and a list of published articles.
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39
Citations
1171
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Recent Articles
1.
MacKenzie A, Sams M, Lin J, Batista C, Lim M, Riarh C, et al.
Mol Immunol
. 2024 Sep;
175:103-111.
PMID: 39332244
Activation-induced cytidine deaminase (AID, encoded by Aicda) plays a key role in somatic hypermutation and class switch recombination in germinal center B cells. However, off-target effects of AID are implicated...
2.
Tazhitdinova R, Cristiano S, Yi J, Zhurov V, DeKoter R, Timoshenko A
J Cell Physiol
. 2024 Apr;
239(6):e31288.
PMID: 38685860
Galectin-12 is a tissue-specific galectin that has been largely defined by its role in the regulation of adipocyte differentiation and lipogenesis. This study aimed to evaluate the role of galectin-12...
3.
Sams M, Iansavitchous J, Astridge M, Rysan H, Xu L, Rodrigues de Oliveira B, et al.
J Pharmacol Exp Ther
. 2024 Feb;
389(1):40-50.
PMID: 38336380
B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young children and is associated with high levels of reactive oxygen species (ROS). The antioxidant N-acetylcysteine (NAC)...
4.
Raczkowski H, Xu L, Wang W, DeKoter R
Immunohorizons
. 2024 Jan;
6(1):104-115.
PMID: 38285436
Spi-C is an E26 transformation-specific transcription factor closely related to PU.1 and Spi-B. Spi-C has lineage-instructive functions important in B cell development, Ab-generating responses, and red pulp macrophage generation. This...
5.
Rodrigues de Oliveira B, Iansavitchous J, Rysan H, Wang W, Sams M, Knight D, et al.
Gene
. 2024 Jan;
900:148131.
PMID: 38216003
Precursor B cell acute lymphoblastic leukemia (Pre-B-ALL) arises from developing B cells and frequently involves mutations in genes encoding transcription factors. In this study, we investigated the function of mutations...
6.
Kim S, Kiser P, Asfaha S, DeKoter R, Dick F
EMBO J
. 2023 Nov;
42(24):e114462.
PMID: 37934086
Mammalian cells repress expression of repetitive genomic sequences by forming heterochromatin. However, the consequences of ectopic repeat expression remain unclear. Here we demonstrate that inhibitors of EZH2, the catalytic subunit...
7.
Xu L, Zhu J, Raczkowski H, Batista C, DeKoter R
J Immunol
. 2023 May;
211(1):71-80.
PMID: 37195219
B cell development requires the ordered rearrangement of Ig genes encoding H and L chain proteins that assemble into BCRs or Abs capable of recognizing specific Ags. Igκ rearrangement is...
8.
Raczkowski H, DeKoter R
WIREs Mech Dis
. 2021 Nov;
13(5):e1519.
PMID: 34730294
Cell fate decisions during hematopoiesis are the consequence of a complex mixture of inputs from cell-intrinsic and cell-extrinsic factors. In rare cases, expression of a single transcription factor, or a...
9.
Lim M, Batista C, de Oliveira B, Creighton R, Ferguson J, Clemmer K, et al.
Mol Cell Biol
. 2020 Jul;
40(18).
PMID: 32631903
Precursor B cell acute lymphoblastic leukemia (B-ALL) is caused by genetic lesions in developing B cells that function as drivers for the accumulation of additional mutations in an evolutionary selection...
10.
Ha S, Cho W, DeKoter R, Kim S
J Biol Chem
. 2019 Oct;
294(46):17487-17500.
PMID: 31586032
The DNA-binding protein PU.1 is a myeloid lineage-determining and pioneering transcription factor due to its ability to bind "closed" genomic sites and maintain "open" chromatin state for myeloid lineage-specific genes....