Robin Verhaar
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Explore the profile of Robin Verhaar including associated specialties, affiliations and a list of published articles.
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10
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200
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Recent Articles
1.
Verhaar R, Drukarch B, Bol J, Jongenelen C, Wilhelmus M
Neurochem Int
. 2013 Feb;
62(4):486-91.
PMID: 23380076
Tissue transglutaminase (tTG) is a cross-linking enzyme involved in protein aggregation during Parkinson's disease (PD) pathogenesis. Autophagy is inhibited by tTG activation via a mechanism in which cross-linking of beclin...
2.
Verhaar R, Drukarch B, Bol J, Jongenelen C, Musters R, Wilhelmus M
Neurobiol Dis
. 2011 Nov;
45(3):839-50.
PMID: 22051113
Parkinson's disease (PD) is characterized by accumulation of α-synuclein aggregates and degeneration of melanized, catecholaminergic neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross-linking. In PD, tTG levels are...
3.
Verhaar R, Jongenelen C, Gerard M, Baekelandt V, Van Dam A, Wilhelmus M, et al.
Neurochem Int
. 2011 Mar;
58(7):785-93.
PMID: 21440023
Transamidation of α-synuclein by the Ca(2+)-dependent enzyme tissue transglutaminase (tTG, EC 2.3.2.13) is implicated in Parkinson's disease (PD). tTG may therefore offer a novel therapeutic target to intervene in PD....
4.
Wilhelmus M, Verhaar R, Andringa G, Bol J, Cras P, Shan L, et al.
Brain Pathol
. 2010 Aug;
21(2):130-9.
PMID: 20731657
Parkinson's disease (PD) is characterized by the accumulation of α-synuclein aggregates and degeneration of melanized neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross-linking. In PD brain, tTG-induced cross-links...
5.
Wilhelmus M, Verhaar R, Bol J, Van Dam A, Hoozemans J, Rozemuller A, et al.
Neurobiol Aging
. 2009 May;
32(5):845-56.
PMID: 19464759
Corpora amylacea (CA) are both age and neurodegeneration-related spherical bodies, consisting of polymerized proteins, often thought to be involved in sequestration of hazardous products of cellular metabolism in brain. Although...
6.
Verhaar R, Dekkers D, De Cuyper I, Ginsberg M, de Korte D, Verhoeven A
Blood
. 2008 Sep;
112(13):4935-9.
PMID: 18796633
UV-C irradiation has been shown to be effective for pathogen reduction in platelet concentrates, but preliminary work indicated that UV-C irradiation of platelets can induce platelet aggregation. In this study,...
7.
Terpstra F, van t Wout A, Schuitemaker H, van Engelenburg F, Dekkers D, Verhaar R, et al.
Transfusion
. 2007 Nov;
48(2):304-13.
PMID: 18028277
Background: Pathogen contamination, causing transfusion-transmitted diseases, is an ongoing concern in transfusion of cellular blood products. In this explorative study, the pathogen-inactivating capacity of UVC irradiation in platelet (PLT) concentrates...
8.
Verhoeven A, Verhaar R, Gouwerok E, de Korte D
Transfusion
. 2005 Jan;
45(1):82-9.
PMID: 15647022
Background: Deterioration of platelet (PLT) quality during storage is accompanied by an increase in lactate production, indicating a decrease in mitochondrial function. In this study, the optimal conditions under which...
9.
de Greeff A, Buys H, Verhaar R, van Alphen L, Smith H
J Clin Microbiol
. 2002 Aug;
40(9):3261-8.
PMID: 12202563
The occurrence of 36 environmentally regulated genes of Streptococcus suis strain 10 among all 35 S. suis serotypes was determined by using hybridization with the amplified genes as probes. In...
10.
de Greeff A, Buys H, Verhaar R, Dijkstra J, van Alphen L, Smith H
Infect Immun
. 2002 Feb;
70(3):1319-25.
PMID: 11854216
In the present study we investigated the role of the fibronectin (FN)- and fibrinogen (FGN)-binding protein (FBPS) in the pathogenesis of Streptococcus suis serotype 2 in piglets. The complete gene...