Robin Meccariello
Overview
Explore the profile of Robin Meccariello including associated specialties, affiliations and a list of published articles.
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7
Citations
192
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0
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Recent Articles
1.
Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation
Beneduce C, Nguyen S, Washburn N, Schaeck J, Meccariello R, Holte K, et al.
Cells
. 2023 Sep;
12(17).
PMID: 37681862
Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the anti-inflammatory activity of IgGs. However, evaluating the structure-activity...
2.
Farutin V, Prodhomme T, McConnell K, Washburn N, Halvey P, Etzel C, et al.
Arthritis Res Ther
. 2019 Oct;
21(1):216.
PMID: 31647025
Background: The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responders...
3.
Washburn N, Meccariello R, Duffner J, Getchell K, Holte K, Prodhomme T, et al.
Mol Cell Proteomics
. 2018 Dec;
18(3):534-545.
PMID: 30559323
The importance of IgG glycosylation, Fc-gamma receptor (FcγR) single nucleotide polymorphisms and FcγR copy number variations in fine tuning the immune response has been well established. There is a growing...
4.
Washburn N, Meccariello R, Hu S, Hains M, Bhatnagar N, Sarvaiya H, et al.
PLoS One
. 2017 Aug;
12(7):e0181251.
PMID: 28759653
Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of healthy donors. Approved IVIg products on the market differ...
5.
Ortiz D, Lansing J, Rutitzky L, Kurtagic E, Prodhomme T, Choudhury A, et al.
Sci Transl Med
. 2016 Nov;
8(365):365ra158.
PMID: 27856797
Autoantibody immune complex (IC) activation of Fcγ receptors (FcγRs) is a common pathogenic hallmark of multiple autoimmune diseases. Given that the IC structural features that elicit FcγR activation are poorly...
6.
Srinivasan K, Roy S, Washburn N, Sipsey S, Meccariello R, Meador 3rd J, et al.
J Biomol Screen
. 2015 Apr;
20(6):768-78.
PMID: 25851037
Fidelity of glycan structures is a key requirement for biotherapeutics, with carbohydrates playing an important role for therapeutic efficacy. Comprehensive glycan profiling techniques such as liquid chromatography (LC) and mass...
7.
Washburn N, Schwab I, Ortiz D, Bhatnagar N, Lansing J, Medeiros A, et al.
Proc Natl Acad Sci U S A
. 2015 Mar;
112(11):E1297-306.
PMID: 25733881
Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain major limitations for patients and physicians using IVIg. These limitations have stimulated...